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'''Tanox''' was an American [[biopharmaceutical]] company that specialized in the discovery and development of [[monoclonal antibodies]]. The company was founded in 1986 by Nancy T. Chang and Tse Wen Chang, and was based in [[Houston]], [[Texas]]. Tanox was known for its work in the field of [[immunology]] and was one of the first companies to develop a monoclonal antibody therapy for the treatment of [[allergies]] and [[asthma]].
== Tanox ==


== History ==
[[File:Tanox-logo.PNG|thumb|right|Tanox logo]]


Tanox was founded in 1986 by Nancy T. Chang and Tse Wen Chang, both of whom had backgrounds in [[molecular biology]] and [[immunology]]. The company was initially focused on the development of monoclonal antibodies for the treatment of allergies and asthma. In 1996, Tanox partnered with [[Novartis]] and [[Genentech]] to develop a monoclonal antibody therapy for [[allergic asthma]], which resulted in the creation of [[Xolair]] (omalizumab).
'''Tanox, Inc.''' was a biopharmaceutical company that focused on the discovery and development of innovative therapeutic antibodies to address significant unmet medical needs in the treatment of immune-mediated diseases, inflammation, infectious disease, and cancer. The company was founded in 1986 and was headquartered in [[Houston, Texas]].


In 2007, Tanox was acquired by Genentech for approximately $919 million. Following the acquisition, Genentech continued the development of Tanox's drug pipeline, which included potential treatments for [[HIV]], [[cancer]], and [[autoimmune diseases]].
=== History ===
Tanox was established by Dr. Nancy Chang and Dr. David Anderson. The company gained prominence for its work in the field of [[monoclonal antibodies]], particularly in the development of treatments for [[allergic diseases]].


== Research and Development ==
In 2007, Tanox was acquired by [[Genentech]], a leading biotechnology company, which is now part of [[Roche]]. This acquisition was part of Genentech's strategy to expand its portfolio of antibody-based therapies.


Tanox's research and development efforts were primarily focused on the discovery and development of monoclonal antibodies. The company's most notable achievement was the development of Xolair, a monoclonal antibody therapy for allergic asthma. Xolair works by binding to and neutralizing [[IgE antibodies]], which are responsible for triggering allergic reactions.
=== Key Developments ===
One of Tanox's most notable achievements was the development of [[omalizumab]], marketed under the brand name [[Xolair]]. Omalizumab is a monoclonal antibody that targets [[immunoglobulin E]] (IgE) and is used in the treatment of moderate to severe [[asthma]] and [[chronic idiopathic urticaria]].


In addition to Xolair, Tanox also developed TNX-355, a monoclonal antibody for the treatment of HIV. TNX-355 works by blocking the entry of HIV into [[T cells]], thereby preventing the virus from replicating and spreading.
The development of omalizumab was a collaborative effort between Tanox, Genentech, and [[Novartis]]. It was approved by the [[U.S. Food and Drug Administration]] (FDA) in 2003 and has since become a significant therapeutic option for patients with severe allergic asthma.


== Legacy ==
=== Research and Development ===
Tanox was involved in various research projects aimed at developing novel therapies for a range of diseases. The company's research focused on the use of monoclonal antibodies to modulate the immune system and treat conditions such as [[autoimmune diseases]], [[cancer]], and [[infectious diseases]].


Tanox's legacy lies in its pioneering work in the field of monoclonal antibody therapy. The company's development of Xolair marked a significant advancement in the treatment of allergies and asthma, and its research into HIV treatments contributed to the understanding of the disease's mechanisms.
=== Acquisition and Legacy ===
The acquisition of Tanox by Genentech allowed for the integration of Tanox's innovative research and development capabilities into Genentech's broader portfolio. This acquisition also facilitated the continued development and commercialization of omalizumab and other potential therapies.


[[Category:Biotechnology companies of the United States]]
Tanox's legacy lies in its pioneering work in the field of monoclonal antibodies and its contribution to the development of therapies that have improved the quality of life for patients with severe allergic conditions.
[[Category:Companies based in Houston]]
 
[[Category:Pharmaceutical companies of the United States]]
== Related pages ==
[[Category:Pharmaceutical companies established in 1986]]
* [[Genentech]]
[[Category:1986 establishments in Texas]]
* [[Monoclonal antibody]]
[[Category:2007 mergers and acquisitions]]
* [[Omalizumab]]
{{Biotech-company-stub}}
* [[Biopharmaceutical]]
 
[[Category:Biotechnology companies]]
[[Category:Defunct companies of the United States]]
[[Category:Companies based in Houston, Texas]]

Latest revision as of 03:44, 13 February 2025

Tanox[edit]

File:Tanox-logo.PNG
Tanox logo

Tanox, Inc. was a biopharmaceutical company that focused on the discovery and development of innovative therapeutic antibodies to address significant unmet medical needs in the treatment of immune-mediated diseases, inflammation, infectious disease, and cancer. The company was founded in 1986 and was headquartered in Houston, Texas.

History[edit]

Tanox was established by Dr. Nancy Chang and Dr. David Anderson. The company gained prominence for its work in the field of monoclonal antibodies, particularly in the development of treatments for allergic diseases.

In 2007, Tanox was acquired by Genentech, a leading biotechnology company, which is now part of Roche. This acquisition was part of Genentech's strategy to expand its portfolio of antibody-based therapies.

Key Developments[edit]

One of Tanox's most notable achievements was the development of omalizumab, marketed under the brand name Xolair. Omalizumab is a monoclonal antibody that targets immunoglobulin E (IgE) and is used in the treatment of moderate to severe asthma and chronic idiopathic urticaria.

The development of omalizumab was a collaborative effort between Tanox, Genentech, and Novartis. It was approved by the U.S. Food and Drug Administration (FDA) in 2003 and has since become a significant therapeutic option for patients with severe allergic asthma.

Research and Development[edit]

Tanox was involved in various research projects aimed at developing novel therapies for a range of diseases. The company's research focused on the use of monoclonal antibodies to modulate the immune system and treat conditions such as autoimmune diseases, cancer, and infectious diseases.

Acquisition and Legacy[edit]

The acquisition of Tanox by Genentech allowed for the integration of Tanox's innovative research and development capabilities into Genentech's broader portfolio. This acquisition also facilitated the continued development and commercialization of omalizumab and other potential therapies.

Tanox's legacy lies in its pioneering work in the field of monoclonal antibodies and its contribution to the development of therapies that have improved the quality of life for patients with severe allergic conditions.

Related pages[edit]