TC-1827: Difference between revisions

Latest revision as of 04:01, 13 February 2025

Topic: Cardiovascular System[edit]

The cardiovascular system, also known as the circulatory system, is an organ system that permits blood to circulate and transport nutrients, oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.

Diagram of the human cardiovascular system

Components[edit]

The cardiovascular system consists of the following major components:

Heart[edit]

The heart is a muscular organ that pumps blood through the blood vessels of the circulatory system. It is located in the thoracic cavity, between the lungs, and is divided into four chambers: the left and right atria and the left and right ventricles.

Blood Vessels[edit]

Blood vessels are the channels through which blood is distributed to body tissues. There are three major types of blood vessels:

Arteries: Vessels that carry blood away from the heart.
Veins: Vessels that carry blood towards the heart.
Capillaries: Microscopic vessels where the exchange of water, oxygen, carbon dioxide, and many other nutrients and waste substances occurs between blood and the tissues.

Blood[edit]

Blood is a specialized bodily fluid that delivers necessary substances to the body's cells and transports waste products away from those same cells. It is composed of red blood cells, white blood cells, platelets, and plasma.

Function[edit]

The primary function of the cardiovascular system is to transport nutrients, gases, and waste products around the body. It also plays a role in maintaining body temperature and pH balance.

Circulation[edit]

The cardiovascular system is responsible for two types of circulation:

Systemic circulation: The part of the cardiovascular system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart.
Pulmonary circulation: The part of the cardiovascular system which carries deoxygenated blood away from the heart, to the lungs, and returns oxygenated blood back to the heart.

Diseases[edit]

Diseases of the cardiovascular system are common and can be serious. Some of the most common cardiovascular diseases include:

Related pages[edit]

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-'''TC-1827''' is a [[nicotinic acetylcholine receptor]] (nAChR) agonist. It is a subtype-selective drug, specifically targeting the α4β2 subtype of nAChR. This receptor subtype is widely distributed in the brain and is believed to be responsible for the cognitive and mood-enhancing effects of nicotine. TC-1827 has been studied for its potential use in the treatment of cognitive disorders such as [[Alzheimer's disease]] and [[attention deficit hyperactivity disorder]] (ADHD).
+== Topic: Cardiovascular System ==
-==Pharmacology==
+The '''cardiovascular system''', also known as the '''circulatory system''', is an organ system that permits blood to circulate and transport nutrients, oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.
-TC-1827 is a full agonist at the α4β2 [[nicotinic acetylcholine receptor]] (nAChR), the most common nAChR subtype in the brain. It has a high affinity for this receptor subtype, and its activation leads to the opening of ion channels in the cell membrane, allowing the flow of sodium and potassium ions into and out of the cell. This results in depolarization of the cell membrane and the generation of an action potential, leading to the release of various neurotransmitters in the brain.
+[[File:TC-1827.svg|thumb|right|Diagram of the human cardiovascular system]]
-==Clinical significance==
+== Components ==
-The α4β2 nAChR subtype is believed to be responsible for the cognitive-enhancing and mood-elevating effects of nicotine. Therefore, drugs that selectively target this receptor subtype, such as TC-1827, have been investigated for their potential use in the treatment of cognitive disorders.
+The cardiovascular system consists of the following major components:
-In preclinical studies, TC-1827 has been shown to improve cognitive performance in animal models of [[Alzheimer's disease]] and [[attention deficit hyperactivity disorder]] (ADHD). However, further research is needed to determine the safety and efficacy of this drug in humans.
+=== Heart ===
-==See also==
+The [[heart]] is a muscular organ that pumps blood through the blood vessels of the circulatory system. It is located in the thoracic cavity, between the lungs, and is divided into four chambers: the left and right atria and the left and right ventricles.
-* [[Nicotinic acetylcholine receptor]]
-* [[Alzheimer's disease]]
-* [[Attention deficit hyperactivity disorder]]
-[[Category:Drugs]]
+=== Blood Vessels ===
-[[Category:Nootropics]]
-[[Category:Neuroscience]]
+Blood vessels are the channels through which blood is distributed to body tissues. There are three major types of blood vessels:
-{{Pharma-stub}}
-{{Neuroscience-stub}}
+* '''[[Arteries]]''': Vessels that carry blood away from the heart.
+* '''[[Veins]]''': Vessels that carry blood towards the heart.
+* '''[[Capillaries]]''': Microscopic vessels where the exchange of water, oxygen, carbon dioxide, and many other nutrients and waste substances occurs between blood and the tissues.
+=== Blood ===
+[[Blood]] is a specialized bodily fluid that delivers necessary substances to the body's cells and transports waste products away from those same cells. It is composed of red blood cells, white blood cells, platelets, and plasma.
+== Function ==
+The primary function of the cardiovascular system is to transport nutrients, gases, and waste products around the body. It also plays a role in maintaining body temperature and pH balance.
+=== Circulation ===
+The cardiovascular system is responsible for two types of circulation:
+* '''[[Systemic circulation]]''': The part of the cardiovascular system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart.
+* '''[[Pulmonary circulation]]''': The part of the cardiovascular system which carries deoxygenated blood away from the heart, to the lungs, and returns oxygenated blood back to the heart.
+== Diseases ==
+Diseases of the cardiovascular system are common and can be serious. Some of the most common cardiovascular diseases include:
+* [[Coronary artery disease]]
+* [[Hypertension]]
+* [[Heart failure]]
+* [[Arrhythmia]]
+== Related pages ==
+* [[Respiratory system]]
+* [[Nervous system]]
+* [[Endocrine system]]
+[[Category:Cardiovascular system]]