JWH-196: Difference between revisions

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'''JWH-196''' is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent and selective CB2 receptor agonist, with a Ki of 2.1 nM and selectivity of around 200 times for CB2 over [[CB1 receptors|CB1]].
{{DISPLAYTITLE:JWH-196}}


==Chemistry==
== Overview ==
JWH-196 is part of the [[JWH series]], a group of synthetic cannabinoids named after the initials of their developer, John W. Huffman. The chemical structure of JWH-196 is characterized by a naphthoyl group, a 3-carbon alkyl chain, and an indole core, which is a common feature of the naphthoylindole family of synthetic cannabinoids.
'''JWH-196''' is a synthetic cannabinoid that acts as a potent agonist at the [[cannabinoid receptor|cannabinoid receptors]]. It is part of the [[JWH series]] of synthetic cannabinoids, which were developed by Dr. [[John W. Huffman]] and his team in the 1990s. These compounds are often used in scientific research to study the [[endocannabinoid system]].


==Pharmacology==
[[File:JWH-196.png|thumb|right|Chemical structure of JWH-196]]
JWH-196 acts as a potent and selective agonist for the [[CB2 receptor]], a type of cannabinoid receptor in the body that is primarily found in the immune system. The Ki value of JWH-196 is 2.1 nM, indicating a high affinity for the CB2 receptor. It has around 200 times selectivity for CB2 over the [[CB1 receptor]], which is primarily found in the brain.


==Effects==
== Chemical Structure ==
The effects of JWH-196 are not well-studied in humans. However, due to its high selectivity for the CB2 receptor, it is unlikely to produce the psychoactive effects typically associated with cannabinoids that activate the CB1 receptor. Instead, it may have potential therapeutic effects related to the immune system, as the CB2 receptor is known to play a role in immune function.
JWH-196 is classified as a naphthoylindole, which is a type of synthetic cannabinoid. Its chemical structure includes a naphthalene group attached to an indole core, which is a common feature among many synthetic cannabinoids in the JWH series. The specific chemical formula for JWH-196 is C24H23NO.


==Legal Status==
== Pharmacology ==
The legal status of JWH-196 varies by country and region. In many places, it is considered a controlled substance due to its structural similarity to other synthetic cannabinoids, which are often subject to legal restrictions.
JWH-196 acts as a full agonist at the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] receptors, which are part of the [[endocannabinoid system]]. This system is involved in regulating various physiological processes, including [[pain]], [[appetite]], and [[mood]]. The binding affinity of JWH-196 to these receptors is similar to that of [[tetrahydrocannabinol|THC]], the primary psychoactive component of [[cannabis]].


==See Also==
== Legal Status ==
* [[JWH-018]]
Due to its potential for abuse and lack of medical use, JWH-196, like many other synthetic cannabinoids, is classified as a controlled substance in many countries. The legal status of these compounds can vary significantly between jurisdictions, and they are often subject to [[drug scheduling|drug scheduling]] laws.
* [[JWH-073]]
 
== Health Effects ==
The use of synthetic cannabinoids like JWH-196 can lead to a range of adverse health effects. These may include [[tachycardia]], [[hypertension]], [[hallucinations]], and [[psychosis]]. The potency and unpredictable nature of these compounds can make them particularly dangerous compared to natural cannabinoids.
 
== Research Applications ==
JWH-196 is primarily used in scientific research to study the [[cannabinoid receptor|cannabinoid receptors]] and the [[endocannabinoid system]]. Researchers use these compounds to better understand the physiological and pharmacological effects of cannabinoid receptor activation.
 
== Related Pages ==
* [[Synthetic cannabinoids]]
* [[Synthetic cannabinoids]]
* [[JWH series]]
* [[Endocannabinoid system]]
* [[Cannabinoid receptor]]
* [[Cannabinoid receptor]]


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:Naphthoylindoles]]
[[Category:Research chemicals]]
{{pharmacology-stub}}
{{chemistry-stub}}

Latest revision as of 04:00, 13 February 2025


Overview[edit]

JWH-196 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the JWH series of synthetic cannabinoids, which were developed by Dr. John W. Huffman and his team in the 1990s. These compounds are often used in scientific research to study the endocannabinoid system.

Chemical structure of JWH-196

Chemical Structure[edit]

JWH-196 is classified as a naphthoylindole, which is a type of synthetic cannabinoid. Its chemical structure includes a naphthalene group attached to an indole core, which is a common feature among many synthetic cannabinoids in the JWH series. The specific chemical formula for JWH-196 is C24H23NO.

Pharmacology[edit]

JWH-196 acts as a full agonist at the CB1 and CB2 receptors, which are part of the endocannabinoid system. This system is involved in regulating various physiological processes, including pain, appetite, and mood. The binding affinity of JWH-196 to these receptors is similar to that of THC, the primary psychoactive component of cannabis.

Legal Status[edit]

Due to its potential for abuse and lack of medical use, JWH-196, like many other synthetic cannabinoids, is classified as a controlled substance in many countries. The legal status of these compounds can vary significantly between jurisdictions, and they are often subject to drug scheduling laws.

Health Effects[edit]

The use of synthetic cannabinoids like JWH-196 can lead to a range of adverse health effects. These may include tachycardia, hypertension, hallucinations, and psychosis. The potency and unpredictable nature of these compounds can make them particularly dangerous compared to natural cannabinoids.

Research Applications[edit]

JWH-196 is primarily used in scientific research to study the cannabinoid receptors and the endocannabinoid system. Researchers use these compounds to better understand the physiological and pharmacological effects of cannabinoid receptor activation.

Related Pages[edit]