Nivacortol: Difference between revisions
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'''Nivacortol''' is a [[ | {{DISPLAYTITLE:Nivacortol}} | ||
==Overview== | |||
'''Nivacortol''' is a synthetic [[glucocorticoid]] used in the treatment of various inflammatory and autoimmune conditions. As a member of the corticosteroid family, it functions by modulating the immune response and reducing inflammation. | |||
==Pharmacology== | ==Pharmacology== | ||
Nivacortol | Nivacortol exerts its effects by binding to the [[glucocorticoid receptor]], which then translocates to the cell nucleus and influences the transcription of specific genes. This action results in the suppression of pro-inflammatory cytokines and the promotion of anti-inflammatory proteins. | ||
== | ==Mechanism of Action== | ||
Nivacortol | The primary mechanism of action of Nivacortol involves the inhibition of [[phospholipase A2]], an enzyme responsible for the release of [[arachidonic acid]] from membrane phospholipids. This inhibition leads to a decrease in the synthesis of [[prostaglandins]] and [[leukotrienes]], both of which are mediators of inflammation. | ||
==Clinical Uses== | |||
Nivacortol is indicated for the management of conditions such as: | |||
* [[Rheumatoid arthritis]] | |||
* [[Asthma]] | |||
* [[Allergic rhinitis]] | |||
* [[Inflammatory bowel disease]] | |||
==Side Effects== | ==Side Effects== | ||
Common side effects associated with Nivacortol include: | |||
* [[Hypertension]] | |||
* [[Hyperglycemia]] | |||
* [[Osteoporosis]] | |||
* [[Cushing's syndrome]] | |||
== | ==Administration== | ||
* [[ | Nivacortol can be administered orally or via injection, depending on the severity of the condition being treated. Dosage and duration of therapy are determined based on the specific needs of the patient and the condition being treated. | ||
* [[ | |||
==Image Gallery== | |||
[[File:Nivacortol.svg|thumb|right|Chemical structure of Nivacortol]] | |||
==Related Pages== | |||
* [[Corticosteroid]] | |||
* [[Glucocorticoid receptor]] | |||
* [[Inflammation]] | * [[Inflammation]] | ||
[[Category:Glucocorticoids]] | [[Category:Glucocorticoids]] | ||
[[Category:Anti-inflammatory agents]] | [[Category:Anti-inflammatory agents]] | ||
Latest revision as of 04:02, 13 February 2025
Overview[edit]
Nivacortol is a synthetic glucocorticoid used in the treatment of various inflammatory and autoimmune conditions. As a member of the corticosteroid family, it functions by modulating the immune response and reducing inflammation.
Pharmacology[edit]
Nivacortol exerts its effects by binding to the glucocorticoid receptor, which then translocates to the cell nucleus and influences the transcription of specific genes. This action results in the suppression of pro-inflammatory cytokines and the promotion of anti-inflammatory proteins.
Mechanism of Action[edit]
The primary mechanism of action of Nivacortol involves the inhibition of phospholipase A2, an enzyme responsible for the release of arachidonic acid from membrane phospholipids. This inhibition leads to a decrease in the synthesis of prostaglandins and leukotrienes, both of which are mediators of inflammation.
Clinical Uses[edit]
Nivacortol is indicated for the management of conditions such as:
Side Effects[edit]
Common side effects associated with Nivacortol include:
Administration[edit]
Nivacortol can be administered orally or via injection, depending on the severity of the condition being treated. Dosage and duration of therapy are determined based on the specific needs of the patient and the condition being treated.
Image Gallery[edit]
