O-1918: Difference between revisions

Latest revision as of 03:36, 13 February 2025

O-1918[edit]

O-1918 is a synthetic compound that acts as a selective antagonist of the cannabinoid receptor GPR55. It is structurally related to the cannabinoid CP-55940, but it has been modified to remove its activity at the classical cannabinoid receptors CB1 and CB2.

Chemical Structure[edit]

O-1918 is a derivative of the cannabinoid CP-55940, with specific modifications that confer its selectivity for GPR55. The chemical structure of O-1918 is characterized by the presence of a phenolic hydroxyl group and a carboxylic acid moiety, which are crucial for its activity as a GPR55 antagonist.

Mechanism of Action[edit]

O-1918 functions primarily as an antagonist of the GPR55 receptor, a G protein-coupled receptor that has been implicated in various physiological processes, including pain, inflammation, and cancer. By blocking GPR55, O-1918 can modulate these processes, making it a compound of interest in pharmacology and therapeutics.

Pharmacological Effects[edit]

The pharmacological effects of O-1918 are primarily related to its action on GPR55. Studies have shown that O-1918 can inhibit GPR55-mediated calcium signaling, which is involved in various cellular responses. This inhibition can lead to reduced cell proliferation and migration, particularly in cancer cells, suggesting potential applications in oncology.

Research Applications[edit]

O-1918 is used extensively in research to study the role of GPR55 in various biological systems. It serves as a valuable tool for dissecting the signaling pathways mediated by GPR55 and for exploring the therapeutic potential of targeting this receptor in diseases such as cancer, neuropathic pain, and inflammatory disorders.

Related Pages[edit]

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-'''O-1918''' is a synthetic compound that was originally identified in the early 2000s. It is often associated with the [[cannabinoid]] system due to its ability to act as an antagonist for the [[GPR18]] receptor, which is a target of interest in the field of [[pharmacology]].
+== O-1918 ==
-== History ==
+[[File:O-1918_structure.png|thumb|right|Chemical structure of O-1918]]
-O-1918 was first identified in the early 2000s. It was initially thought to be an antagonist for the [[CB1 receptor]] and [[CB2 receptor]], which are the primary targets of the [[cannabinoid]] system. However, subsequent research has shown that O-1918 does not have significant activity at these receptors. Instead, it has been found to act as an antagonist for the [[GPR18]] receptor.
+'''O-1918''' is a synthetic compound that acts as a selective antagonist of the [[cannabinoid receptor]] [[GPR55]]. It is structurally related to the cannabinoid [[CP-55940]], but it has been modified to remove its activity at the classical [[cannabinoid receptors]] [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]].
-== Pharmacology ==
+== Chemical Structure ==
-The primary target of O-1918 is the [[GPR18]] receptor. This receptor is a member of the [[G protein-coupled receptor]] family and is expressed in various tissues throughout the body, including the [[central nervous system]] and [[immune system]]. The exact role of GPR18 is still not fully understood, but it is thought to be involved in a variety of physiological processes, including [[inflammation]], [[pain perception]], and [[immune response]].
+O-1918 is a derivative of the [[cannabinoid]] CP-55940, with specific modifications that confer its selectivity for GPR55. The chemical structure of O-1918 is characterized by the presence of a [[phenolic]] hydroxyl group and a [[carboxylic acid]] moiety, which are crucial for its activity as a GPR55 antagonist.
-O-1918 acts as an antagonist for the GPR18 receptor, meaning that it blocks the receptor's activity. This can potentially be used to modulate the receptor's effects, although the exact therapeutic potential of O-1918 is still under investigation.
+== Mechanism of Action ==
-== Research and Potential Therapeutic Uses ==
+O-1918 functions primarily as an antagonist of the GPR55 receptor, a [[G protein-coupled receptor]] that has been implicated in various physiological processes, including [[pain]], [[inflammation]], and [[cancer]]. By blocking GPR55, O-1918 can modulate these processes, making it a compound of interest in [[pharmacology]] and [[therapeutics]].
-Research into O-1918 and the GPR18 receptor is still in its early stages. However, due to the wide expression of GPR18 and its involvement in various physiological processes, there is significant interest in the potential therapeutic uses of O-1918.
+== Pharmacological Effects ==
-Some potential areas of interest include the treatment of [[chronic pain]], [[inflammatory diseases]], and [[neurodegenerative diseases]]. However, more research is needed to fully understand the potential benefits and risks of O-1918.
+The pharmacological effects of O-1918 are primarily related to its action on GPR55. Studies have shown that O-1918 can inhibit GPR55-mediated [[calcium]] signaling, which is involved in various cellular responses. This inhibition can lead to reduced [[cell proliferation]] and [[migration]], particularly in cancer cells, suggesting potential applications in [[oncology]].
-== See Also ==
+== Research Applications ==
-* [[Cannabinoid]]
+O-1918 is used extensively in research to study the role of GPR55 in various biological systems. It serves as a valuable tool for dissecting the signaling pathways mediated by GPR55 and for exploring the therapeutic potential of targeting this receptor in diseases such as [[cancer]], [[neuropathic pain]], and [[inflammatory disorders]].
-* [[G protein-coupled receptor]]
-* [[Pharmacology]]
+== Related Pages ==
+* [[Cannabinoid receptor]]
+* [[GPR55]]
+* [[CP-55940]]
+* [[CB1 receptor]]
+* [[CB2 receptor]]
+[[Category:Cannabinoids]]
 [[Category:Pharmacology]]
-[[Category:Synthetic compounds]]
+[[Category:Research tools]]
-[[Category:Cannabinoids]]
-{{stub}}