IRF2

IRF2

Interferon regulatory factor 2 (IRF2) is a protein that in humans is encoded by the IRF2 gene. It is a member of the interferon regulatory transcription factor (IRF) family. IRF2 competes with IRF1 for binding to the interferon-stimulated response element (ISRE) in interferon-mediated gene expression.

Function

IRF2 is a transcriptional repressor that binds to the ISRE and represses interferon-stimulated transcription. In addition, IRF2 has been shown to repress transcription via other mechanisms, and it is thought to play a role in the cellular response to viral infection.

Clinical significance

Mutations in the IRF2 gene have been associated with a variety of diseases, including autoimmune diseases, cancer, and viral infections. The role of IRF2 in these diseases is not fully understood, but it is thought to be involved in the regulation of the immune response.

See also

• Interferon regulatory factors
• Interferon

References

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External links

• IRF2 at the National Center for Biotechnology Information

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