TOLLIP

TOLLIP (Toll Interacting Protein) is a protein that in humans is encoded by the TOLLIP gene. It is involved in the innate immune response to bacterial pathogens. The protein interacts with toll-like receptor 4 through its extracellular domain and contributes to the activation of IL-1 genes.

Function

TOLLIP is an adaptor protein that is involved in the TLR and IL-1R signaling pathways. The protein interacts with several other proteins in these pathways, including MyD88, IL-1RI, and TLR4.

Clinical significance

Mutations in the TOLLIP gene have been associated with susceptibility to infectious diseases, including Tuberculosis and Meningitis. In addition, variations in this gene may be involved in the development of Asthma and COPD.

See also

• Toll-like receptor
• Interleukin 1 receptor
• Myeloid differentiation primary response 88

References

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External links

• TOLLIP at the NCBI Gene

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