MDMB-CHMICA: Difference between revisions

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'''MDMB-CHMICA''' (also incorrectly known as '''MMB-CHMINACA''') is an [[indole]]-based [[synthetic cannabinoid]] that is a potent [[agonist]] of the [[CB1 receptor]] and has been sold online as a [[designer drug]]. While MDMB-CHMICA was initially sold under the name "MMB-CHMINACA", the compound corresponding to this code name (i.e. the [[isopropyl]] instead of [[tert-butyl]] analogue of [[MDMB-CHMINACA]]) has been identified on the designer drug market in 2015 as [[AMB-CHMINACA]].
{{DISPLAYTITLE:MDMB-CHMICA}}


==Pharmacology==
== Overview ==
MDMB-CHMICA acts as a highly potent full agonist of the CB1 receptor with an [[efficacy]] of 94% and an [[EC50]] value of 0.14 nM, which is approximately 8 times lower than the EC50 of [[JWH-018]] (1.13 nM) and twofold lower than that of [[AB-CHMINACA]] (0.27 nM).
'''MDMB-CHMICA''' is a synthetic cannabinoid that has been used as a designer drug. It is a potent agonist of the [[cannabinoid receptor]]s and is often found in products marketed as "[[spice (drug)|spice]]" or "synthetic marijuana." MDMB-CHMICA is known for its high potency and potential for adverse effects.


==Side effects==
== Chemical Structure ==
The side effects of MDMB-CHMICA are not well documented, but reports from users suggest that the effects are similar to those of other potent synthetic cannabinoids. These may include [[psychosis]], [[seizures]], [[agitation]], [[tachycardia]], and [[cardiac arrest]].
[[File:MDMB-CHMICA.svg|thumb|right|Chemical structure of MDMB-CHMICA]]
MDMB-CHMICA is chemically classified as an indole-3-carboxamide. Its full chemical name is ''methyl 2-[[1-(cyclohexylmethyl)-1H-indole-3-carbonyl]amino]-3,3-dimethylbutanoate''. The structure includes a cyclohexylmethyl group attached to the indole core, which is a common feature in many synthetic cannabinoids.


==Legal status==
== Pharmacology ==
As of October 2015, MDMB-CHMICA is a controlled substance in China. It is also banned in Sweden, and the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) issued a warning about the substance in 2014.
MDMB-CHMICA acts as a full agonist at the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors. These receptors are part of the [[endocannabinoid system]], which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation. The high affinity and efficacy of MDMB-CHMICA at these receptors contribute to its potent psychoactive effects.


==See also==
== Effects and Toxicity ==
* [[List of AM cannabinoids]]
The effects of MDMB-CHMICA can include euphoria, altered perception, and relaxation, similar to those of [[tetrahydrocannabinol|THC]], the active component of cannabis. However, due to its high potency, MDMB-CHMICA can also cause severe adverse effects such as [[tachycardia]], [[hypertension]], [[nausea]], [[vomiting]], [[anxiety]], [[paranoia]], and [[hallucinations]]. In some cases, it has been associated with [[seizures]] and [[acute kidney injury]].
* [[List of JWH cannabinoids]]
* [[5F-AB-PINACA]]
* [[5F-ADB]]
* [[5F-AMB]]
* [[5F-APINACA]]


== Legal Status ==
Due to its potential for abuse and adverse health effects, MDMB-CHMICA has been classified as a controlled substance in many countries. It is often included in legislation targeting synthetic cannabinoids and other new psychoactive substances.
== Related Pages ==
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]
* [[Spice (drug)]]
* [[Endocannabinoid system]]
[[Category:Synthetic cannabinoids]]
[[Category:Designer drugs]]
[[Category:Designer drugs]]
[[Category:Cannabinoids]]
[[Category:Indoles]]
{{stub}}
{{Pharmacology-stub}}
{{Psychoactive drug stub}}

Latest revision as of 03:41, 13 February 2025


Overview[edit]

MDMB-CHMICA is a synthetic cannabinoid that has been used as a designer drug. It is a potent agonist of the cannabinoid receptors and is often found in products marketed as "spice" or "synthetic marijuana." MDMB-CHMICA is known for its high potency and potential for adverse effects.

Chemical Structure[edit]

Chemical structure of MDMB-CHMICA

MDMB-CHMICA is chemically classified as an indole-3-carboxamide. Its full chemical name is methyl 2-[[1-(cyclohexylmethyl)-1H-indole-3-carbonyl]amino]-3,3-dimethylbutanoate. The structure includes a cyclohexylmethyl group attached to the indole core, which is a common feature in many synthetic cannabinoids.

Pharmacology[edit]

MDMB-CHMICA acts as a full agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation. The high affinity and efficacy of MDMB-CHMICA at these receptors contribute to its potent psychoactive effects.

Effects and Toxicity[edit]

The effects of MDMB-CHMICA can include euphoria, altered perception, and relaxation, similar to those of THC, the active component of cannabis. However, due to its high potency, MDMB-CHMICA can also cause severe adverse effects such as tachycardia, hypertension, nausea, vomiting, anxiety, paranoia, and hallucinations. In some cases, it has been associated with seizures and acute kidney injury.

Legal Status[edit]

Due to its potential for abuse and adverse health effects, MDMB-CHMICA has been classified as a controlled substance in many countries. It is often included in legislation targeting synthetic cannabinoids and other new psychoactive substances.

Related Pages[edit]