JWH-167: Difference between revisions

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'''JWH-167''' is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent and selective CB2 receptor agonist. It was discovered and named after John W. Huffman, a researcher at Clemson University.
{{DISPLAYTITLE:JWH-167}}


==Chemistry==
== JWH-167 ==
JWH-167 is part of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as [[JWH-018]] and [[JWH-073]]. The compound is a potent and selective agonist for the CB2 receptor, with a binding affinity of 2.94 nM, and 100 times selectivity over the CB1 receptor.
[[File:JWH-167.svg|thumb|right|Chemical structure of JWH-167]]
'''JWH-167''' is a synthetic [[cannabinoid]] that acts as a potent agonist at the [[cannabinoid receptor]]s. It is part of the [[naphthoylindole]] family of compounds, which are known for their high affinity and selectivity for the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] receptors.


==Pharmacology==
=== Chemical Properties ===
The [[CB2 receptor]] is primarily found in the immune system, and is less prevalent in the brain than the CB1 receptor. Activation of the CB2 receptor leads to anti-inflammatory and potentially anti-cancer effects. However, the exact mechanisms of action of JWH-167 are not fully understood, and further research is needed to determine its potential therapeutic uses and side effects.
JWH-167 is characterized by its chemical structure, which includes a naphthoyl group attached to an indole core. The molecular formula of JWH-167 is C23H21NO, and it has a molecular weight of 327.42 g/mol. The compound is typically synthesized in a laboratory setting and is not found naturally in any plant or organism.


==Legal Status==
=== Pharmacology ===
As a synthetic cannabinoid, JWH-167 is illegal in many countries. It is often included in the same legal category as cannabis and other synthetic cannabinoids. However, the legal status can vary by country and even by state or region within a country.
JWH-167 functions as a full agonist at both the CB1 and CB2 receptors, which are part of the [[endocannabinoid system]]. This system plays a crucial role in regulating various physiological processes, including [[pain]], [[appetite]], [[mood]], and [[memory]]. The activation of these receptors by JWH-167 can lead to effects similar to those produced by [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]].


==See Also==
=== Legal Status ===
* [[Synthetic cannabinoids]]
Due to its potential for abuse and lack of medical use, JWH-167, like many other synthetic cannabinoids, is classified as a controlled substance in many jurisdictions. The legal status of JWH-167 can vary significantly from one country to another, and it is important to consult local regulations for specific information.
 
=== Research and Applications ===
Research on JWH-167 and other synthetic cannabinoids is ongoing, with studies focusing on their pharmacological properties, potential therapeutic uses, and risks associated with their use. These compounds are often used in scientific research to better understand the [[endocannabinoid system]] and to develop new treatments for various medical conditions.
 
== Related Pages ==
* [[Cannabinoid receptor]]
* [[Cannabinoid receptor]]
* [[John W. Huffman]]
* [[Synthetic cannabinoid]]
 
* [[Endocannabinoid system]]
==References==
* [[JWH-018]]
<references />
* [[Naphthoylindole]]


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:CB2 receptor agonists]]
[[Category:Chemical compounds]]
[[Category:Naphthoylindoles]]
 
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Latest revision as of 03:35, 13 February 2025


JWH-167[edit]

Chemical structure of JWH-167

JWH-167 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their high affinity and selectivity for the CB1 and CB2 receptors.

Chemical Properties[edit]

JWH-167 is characterized by its chemical structure, which includes a naphthoyl group attached to an indole core. The molecular formula of JWH-167 is C23H21NO, and it has a molecular weight of 327.42 g/mol. The compound is typically synthesized in a laboratory setting and is not found naturally in any plant or organism.

Pharmacology[edit]

JWH-167 functions as a full agonist at both the CB1 and CB2 receptors, which are part of the endocannabinoid system. This system plays a crucial role in regulating various physiological processes, including pain, appetite, mood, and memory. The activation of these receptors by JWH-167 can lead to effects similar to those produced by tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Legal Status[edit]

Due to its potential for abuse and lack of medical use, JWH-167, like many other synthetic cannabinoids, is classified as a controlled substance in many jurisdictions. The legal status of JWH-167 can vary significantly from one country to another, and it is important to consult local regulations for specific information.

Research and Applications[edit]

Research on JWH-167 and other synthetic cannabinoids is ongoing, with studies focusing on their pharmacological properties, potential therapeutic uses, and risks associated with their use. These compounds are often used in scientific research to better understand the endocannabinoid system and to develop new treatments for various medical conditions.

Related Pages[edit]