Cryofibrinogenemia: Difference between revisions
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{{Infobox medical condition | |||
| name = Cryofibrinogenemia | |||
| synonyms = | |||
| field = [[Hematology]] | |||
| symptoms = [[Purpura]], [[ulceration]], [[gangrene]], [[Raynaud's phenomenon]] | |||
| complications = [[Thrombosis]], [[skin necrosis]] | |||
| onset = | |||
| duration = | |||
| types = Primary, Secondary | |||
| causes = Idiopathic, [[Malignancy]], [[Infection]], [[Autoimmune disease]] | |||
| risks = | |||
| diagnosis = [[Blood test]], [[Cryoprecipitate]] analysis | |||
| differential = [[Cryoglobulinemia]], [[Cold agglutinin disease]] | |||
| prevention = | |||
| treatment = [[Fibrinolytic therapy]], [[Plasmapheresis]], [[Immunosuppressive therapy]] | |||
| medication = [[Anticoagulants]], [[Corticosteroids]] | |||
| prognosis = Variable, depends on underlying cause | |||
| frequency = Rare | |||
}} | |||
'''Cryofibrinogenemia''' is a rare [[blood disorder]] characterized by the presence of [[cryofibrinogen]] in the blood. Cryofibrinogen is a type of [[protein]] that becomes insoluble at low temperatures. This condition can lead to various symptoms, including [[skin ulcers]], [[pain]], and [[gangrene]]. | '''Cryofibrinogenemia''' is a rare [[blood disorder]] characterized by the presence of [[cryofibrinogen]] in the blood. Cryofibrinogen is a type of [[protein]] that becomes insoluble at low temperatures. This condition can lead to various symptoms, including [[skin ulcers]], [[pain]], and [[gangrene]]. | ||
== Symptoms == | == Symptoms == | ||
The symptoms of cryofibrinogenemia can vary widely, but often include: | The symptoms of cryofibrinogenemia can vary widely, but often include: | ||
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* [[Livedo reticularis]] | * [[Livedo reticularis]] | ||
* [[Purpura]] | * [[Purpura]] | ||
== Causes == | == Causes == | ||
The exact cause of cryofibrinogenemia is unknown. However, it is often associated with other conditions, such as: | The exact cause of cryofibrinogenemia is unknown. However, it is often associated with other conditions, such as: | ||
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* [[Malignancies]] | * [[Malignancies]] | ||
* [[Infections]] | * [[Infections]] | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of cryofibrinogenemia is based on the detection of cryofibrinogen in the blood. This is usually done through a [[blood test]] that involves cooling the blood sample to see if cryofibrinogen forms. | Diagnosis of cryofibrinogenemia is based on the detection of cryofibrinogen in the blood. This is usually done through a [[blood test]] that involves cooling the blood sample to see if cryofibrinogen forms. | ||
== Treatment == | == Treatment == | ||
Treatment for cryofibrinogenemia typically involves addressing the underlying condition. This may include: | Treatment for cryofibrinogenemia typically involves addressing the underlying condition. This may include: | ||
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* [[Chemotherapy]] or [[radiation therapy]] for malignancies | * [[Chemotherapy]] or [[radiation therapy]] for malignancies | ||
* [[Antibiotics]] for infections | * [[Antibiotics]] for infections | ||
In some cases, [[plasmapheresis]] may be used to remove cryofibrinogen from the blood. | In some cases, [[plasmapheresis]] may be used to remove cryofibrinogen from the blood. | ||
== See also == | == See also == | ||
* [[Cryoglobulinemia]] | * [[Cryoglobulinemia]] | ||
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* [[Hepatitis C]] | * [[Hepatitis C]] | ||
* [[Autoimmune diseases]] | * [[Autoimmune diseases]] | ||
[[Category:Blood disorders]] | [[Category:Blood disorders]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 01:51, 4 April 2025
| Cryofibrinogenemia | |
|---|---|
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Purpura, ulceration, gangrene, Raynaud's phenomenon |
| Complications | Thrombosis, skin necrosis |
| Onset | |
| Duration | |
| Types | Primary, Secondary |
| Causes | Idiopathic, Malignancy, Infection, Autoimmune disease |
| Risks | |
| Diagnosis | Blood test, Cryoprecipitate analysis |
| Differential diagnosis | Cryoglobulinemia, Cold agglutinin disease |
| Prevention | |
| Treatment | Fibrinolytic therapy, Plasmapheresis, Immunosuppressive therapy |
| Medication | Anticoagulants, Corticosteroids |
| Prognosis | Variable, depends on underlying cause |
| Frequency | Rare |
| Deaths | N/A |
Cryofibrinogenemia is a rare blood disorder characterized by the presence of cryofibrinogen in the blood. Cryofibrinogen is a type of protein that becomes insoluble at low temperatures. This condition can lead to various symptoms, including skin ulcers, pain, and gangrene.
Symptoms[edit]
The symptoms of cryofibrinogenemia can vary widely, but often include:
Causes[edit]
The exact cause of cryofibrinogenemia is unknown. However, it is often associated with other conditions, such as:
Diagnosis[edit]
Diagnosis of cryofibrinogenemia is based on the detection of cryofibrinogen in the blood. This is usually done through a blood test that involves cooling the blood sample to see if cryofibrinogen forms.
Treatment[edit]
Treatment for cryofibrinogenemia typically involves addressing the underlying condition. This may include:
- Antiviral therapy for hepatitis C
- Immunosuppressive therapy for autoimmune diseases
- Chemotherapy or radiation therapy for malignancies
- Antibiotics for infections
In some cases, plasmapheresis may be used to remove cryofibrinogen from the blood.
