Ouabain

Ouabain is a cardiac glycoside that is found in a number of plants, including the Acokanthera schimperi and Strophanthus gratus. It is a toxin that can cause cardiac arrest and is often used in scientific research because of its effects on the heart and sodium-potassium pump.

History

Ouabain was first discovered in the 19th century and has been used in traditional medicine in Africa for centuries. It was originally used as a poison for hunting, but has since been found to have potential therapeutic uses.

Mechanism of Action

Ouabain works by inhibiting the sodium-potassium pump, which is an essential mechanism in the cells of the heart. This inhibition leads to an increase in intracellular sodium, which then leads to an increase in intracellular calcium. This increase in calcium can cause the heart to contract more forcefully.

Medical Uses

While ouabain is a potent poison, it has also been found to have potential therapeutic uses. It has been used in the treatment of congestive heart failure and arrhythmia. However, its use is limited due to its narrow therapeutic window and the risk of toxicity.

Side Effects

The side effects of ouabain can be severe and include nausea, vomiting, diarrhea, abdominal pain, and cardiac arrhythmia. In severe cases, it can cause cardiac arrest and death.

Research

Research is ongoing into the potential uses of ouabain in medicine. Some studies have suggested that it may have potential as a treatment for cancer, although more research is needed in this area.

See Also

• Cardiac glycoside
• Sodium-potassium pump
• Congestive heart failure
• Arrhythmia

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Ouabain

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  Chemical structure of Ouabain
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  Acokanthera schimperi plant illustration
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  Strophanthus gratus plant
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  Lophiomys imhausi (Maned rat)
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  Summary of Ouabain synthesis