Methoxamine

Methoxamine is a vasoconstrictor that is used in many medical treatments. It is a direct-acting alpha-adrenergic agonist that is used to treat hypotension and to maintain blood pressure during anesthesia.

Pharmacology

Methoxamine works by stimulating alpha-adrenergic receptors in the smooth muscle of blood vessels, which causes the vessels to constrict. This increases vascular resistance and raises blood pressure.

Uses

Methoxamine is used to treat hypotension, particularly in patients undergoing anesthesia. It is also used in some cases to treat orthostatic hypotension, a condition in which blood pressure falls when a person stands up.

Side Effects

Like all medications, methoxamine can cause side effects. These may include headache, palpitations, and chest pain. In rare cases, it can cause severe hypertension.

Contraindications

Methoxamine should not be used in patients with severe hypertension, pheochromocytoma, or coronary artery disease. It should also be used with caution in patients with prostatic hyperplasia or diabetes.

Interactions

Methoxamine can interact with other medications, including beta-blockers, antidepressants, and MAO inhibitors. These interactions can increase the risk of side effects and should be monitored closely by a healthcare provider.

See Also

• Vasoconstrictor
• Alpha-adrenergic agonist
• Hypotension
• Anesthesia

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