Proscillaridin: Difference between revisions
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{{DISPLAYTITLE:Proscillaridin}} | |||
== | == Proscillaridin == | ||
[[File:Proscillaridin_structure.svg|thumb|right|Chemical structure of Proscillaridin]] | |||
Proscillaridin | '''Proscillaridin''' is a [[cardiac glycoside]] derived from the plant species ''[[Urginea maritima]]'', commonly known as the [[squill]]. It is used in the treatment of certain [[cardiac conditions]], particularly [[congestive heart failure]] and [[arrhythmias]]. Proscillaridin is known for its ability to increase the force of [[myocardial contraction]] and to regulate [[heart rate]]. | ||
== | == Chemical Structure == | ||
Proscillaridin is a [[steroid]] glycoside, characterized by its unique chemical structure that includes a [[steroidal nucleus]] and a sugar moiety. The structure of proscillaridin is crucial for its biological activity, as it interacts with the [[sodium-potassium ATPase]] pump in [[cardiac cells]]. This interaction leads to an increase in intracellular [[calcium]] concentration, which enhances cardiac contractility. | |||
Proscillaridin is used in the | == Mechanism of Action == | ||
Proscillaridin exerts its effects primarily by inhibiting the [[Na+/K+ ATPase]] pump. This inhibition results in an increase in intracellular sodium levels, which in turn affects the [[Na+/Ca2+ exchanger]], leading to an increase in intracellular calcium. The elevated calcium levels enhance the contractile force of the heart muscle, making proscillaridin effective in treating heart failure. | |||
== Clinical Uses == | |||
Proscillaridin is used in the management of [[heart failure]] and certain types of [[arrhythmias]]. It is particularly useful in patients who have not responded adequately to other treatments. The drug helps to improve symptoms such as [[dyspnea]], [[fatigue]], and [[edema]] by increasing cardiac output and reducing the workload on the heart. | |||
== Side Effects == | == Side Effects == | ||
Like other cardiac glycosides, proscillaridin can cause a range of side effects, particularly if not dosed correctly. Common side effects include [[nausea]], [[vomiting]], [[diarrhea]], and [[dizziness]]. More serious side effects can include [[arrhythmias]], [[bradycardia]], and [[electrolyte imbalances]]. Monitoring of [[serum potassium]] and [[renal function]] is important during treatment. | |||
== Related Pages == | |||
== | |||
* [[Cardiac glycoside]] | * [[Cardiac glycoside]] | ||
* [[Congestive heart failure]] | * [[Congestive heart failure]] | ||
* [[ | * [[Arrhythmia]] | ||
* [[Sodium-potassium pump]] | |||
* [[Urginea maritima]] | |||
[[Category:Cardiac glycosides]] | [[Category:Cardiac glycosides]] | ||
[[Category: | [[Category:Pharmacology]] | ||
Latest revision as of 05:23, 16 February 2025
Proscillaridin[edit]
Proscillaridin is a cardiac glycoside derived from the plant species Urginea maritima, commonly known as the squill. It is used in the treatment of certain cardiac conditions, particularly congestive heart failure and arrhythmias. Proscillaridin is known for its ability to increase the force of myocardial contraction and to regulate heart rate.
Chemical Structure[edit]
Proscillaridin is a steroid glycoside, characterized by its unique chemical structure that includes a steroidal nucleus and a sugar moiety. The structure of proscillaridin is crucial for its biological activity, as it interacts with the sodium-potassium ATPase pump in cardiac cells. This interaction leads to an increase in intracellular calcium concentration, which enhances cardiac contractility.
Mechanism of Action[edit]
Proscillaridin exerts its effects primarily by inhibiting the Na+/K+ ATPase pump. This inhibition results in an increase in intracellular sodium levels, which in turn affects the Na+/Ca2+ exchanger, leading to an increase in intracellular calcium. The elevated calcium levels enhance the contractile force of the heart muscle, making proscillaridin effective in treating heart failure.
Clinical Uses[edit]
Proscillaridin is used in the management of heart failure and certain types of arrhythmias. It is particularly useful in patients who have not responded adequately to other treatments. The drug helps to improve symptoms such as dyspnea, fatigue, and edema by increasing cardiac output and reducing the workload on the heart.
Side Effects[edit]
Like other cardiac glycosides, proscillaridin can cause a range of side effects, particularly if not dosed correctly. Common side effects include nausea, vomiting, diarrhea, and dizziness. More serious side effects can include arrhythmias, bradycardia, and electrolyte imbalances. Monitoring of serum potassium and renal function is important during treatment.
