Veristrat: Difference between revisions

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'''VeriStrat®''' is a test developed to evaluate patient prognosis and, additionally, predict benefit from cancer treatment by [[EGFR inhibitor]]s. It is a serum/plasma [[proteomics|proteomic]] test developed using matrix-assisted laser desorption/ionization ([[MALDI]]) [[mass spectrometry]].
{{Short description|A blood-based test for cancer prognosis}}
VeriStrat was developed by [http://www.biodesix.com Biodesix, Inc.], a molecular diagnostics company based in Boulder, CO, USA.


The VeriStrat [[algorithm]] has been interrogated retrospectively and prospectively in samples from randomised trials, such as the PROSE study, confirming the prognostic information associated with the [[molecular signature]]. In addition, the test appeared to be predictive of [[erlotinib]] impact on survival, as only "VeriStrat Good patients" benefited from such a treatment. Additional studies have confirmed its clinical relevance.<ref name="pmid24308656">{{cite journal | vauthors = Molina-Pinelo S, Pastor MD, Paz-Ares L | title = VeriStrat: a prognostic and/or predictive biomarker for advanced lung cancer patients? | journal = Expert Rev Respir Med | volume = 8 | issue = 1 | pages = 1–4 | year = 2014 | pmid = 24308656 | doi = 10.1586/17476348.2014.861744 | url = }}</ref>
'''Veristrat''' is a [[blood test]] used in the field of [[oncology]] to help determine the prognosis of patients with certain types of [[cancer]], particularly [[non-small cell lung cancer]] (NSCLC). This test analyzes the [[proteomic]] profile of a patient's blood to classify them into different prognostic groups, which can guide treatment decisions.


==References==
==Overview==
{{reflist}}
Veristrat is a [[serum]]-based test that utilizes [[mass spectrometry]] to analyze the [[protein]] composition of a patient's blood. The test is designed to provide information about the likely course of the disease and the potential benefit of specific [[chemotherapy]] regimens. It is particularly used in the context of advanced NSCLC to help oncologists decide whether a patient is more likely to benefit from [[chemotherapy]] or [[targeted therapy]].
* Original article describing the test: http://jnci.oxfordjournals.org/content/99/11/838.full.pdf+html
 
[[Category:Medical tests]]
==Mechanism==
[[Category:Targeted therapy]]
The Veristrat test works by examining the [[proteomic]] profile of a patient's blood. It identifies specific patterns of [[protein]] expression that are associated with different outcomes in cancer treatment. The test categorizes patients into "Good" or "Poor" prognostic groups based on these patterns. Patients classified as "Good" are more likely to respond positively to certain treatments, while those in the "Poor" group may have a less favorable response.
 
==Clinical Use==
Veristrat is primarily used in the management of advanced [[non-small cell lung cancer]]. It helps in making informed decisions about the use of [[epidermal growth factor receptor]] (EGFR) inhibitors and other therapies. By providing prognostic information, Veristrat assists in tailoring treatment plans to the individual needs of patients, potentially improving outcomes and avoiding unnecessary side effects from ineffective treatments.
 
==Advantages==
One of the main advantages of Veristrat is its non-invasive nature, as it only requires a blood sample. This makes it a convenient option for patients compared to more invasive procedures like [[biopsy]]. Additionally, the test provides rapid results, allowing for timely decision-making in the management of cancer.


*Lung Cancer Journal, “Outcome and economic implications of proteomic test-guided second- or third-line treatment for advanced non-small cell lung cancer: Extended analysis of the PROSE trial”, Hornberger et al.
==Limitations==
While Veristrat offers valuable prognostic information, it is not a diagnostic test and should be used in conjunction with other clinical assessments and diagnostic tools. The test's predictive power is also limited to certain types of cancer and may not be applicable to all patients or cancer types.


*"Predictive value of a proteomic signature in patients with non-small cell lung cancer treated with second-line erlotinib or chemotherapy (PROSE): a biomarker stratified, randomised phase 3 trial," Gregorc et al. The Lancet Oncology
==Related pages==
* [[Non-small cell lung cancer]]
* [[Proteomics]]
* [[Mass spectrometry]]
* [[Chemotherapy]]
* [[Targeted therapy]]


*A Retrospective Analysis of VeriStrat Status on Outcome of a Randomized Phase II Trial of First-Line Therapy with Gemcitabine, Erlotinib, or the Combination in Elderly Patients (Age 70 Years or Older) with Stage IIIB/IV Non-Small-Cell Lung Cancer. Stinchcombe, et al. Journal of Thoracic Oncology.
[[Category:Oncology]]
{{oncology-stub}}
[[Category:Medical tests]]
{{stb}}
[[Category:Proteomics]]
{{stb}}
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Latest revision as of 19:08, 22 March 2025

A blood-based test for cancer prognosis


Veristrat is a blood test used in the field of oncology to help determine the prognosis of patients with certain types of cancer, particularly non-small cell lung cancer (NSCLC). This test analyzes the proteomic profile of a patient's blood to classify them into different prognostic groups, which can guide treatment decisions.

Overview[edit]

Veristrat is a serum-based test that utilizes mass spectrometry to analyze the protein composition of a patient's blood. The test is designed to provide information about the likely course of the disease and the potential benefit of specific chemotherapy regimens. It is particularly used in the context of advanced NSCLC to help oncologists decide whether a patient is more likely to benefit from chemotherapy or targeted therapy.

Mechanism[edit]

The Veristrat test works by examining the proteomic profile of a patient's blood. It identifies specific patterns of protein expression that are associated with different outcomes in cancer treatment. The test categorizes patients into "Good" or "Poor" prognostic groups based on these patterns. Patients classified as "Good" are more likely to respond positively to certain treatments, while those in the "Poor" group may have a less favorable response.

Clinical Use[edit]

Veristrat is primarily used in the management of advanced non-small cell lung cancer. It helps in making informed decisions about the use of epidermal growth factor receptor (EGFR) inhibitors and other therapies. By providing prognostic information, Veristrat assists in tailoring treatment plans to the individual needs of patients, potentially improving outcomes and avoiding unnecessary side effects from ineffective treatments.

Advantages[edit]

One of the main advantages of Veristrat is its non-invasive nature, as it only requires a blood sample. This makes it a convenient option for patients compared to more invasive procedures like biopsy. Additionally, the test provides rapid results, allowing for timely decision-making in the management of cancer.

Limitations[edit]

While Veristrat offers valuable prognostic information, it is not a diagnostic test and should be used in conjunction with other clinical assessments and diagnostic tools. The test's predictive power is also limited to certain types of cancer and may not be applicable to all patients or cancer types.

Related pages[edit]