IgG deficiency: Difference between revisions
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{{Infobox medical condition | |||
| name = IgG deficiency | |||
| image = [[File:IgG_molecular_surface.jpg|250px]] | |||
| caption = Molecular surface of an IgG antibody | |||
| synonyms = Immunoglobulin G deficiency | |||
| field = [[Immunology]] | |||
| symptoms = Recurrent [[infections]], particularly of the [[sinuses]] and [[lungs]] | |||
| complications = Increased risk of [[autoimmune diseases]] | |||
| onset = Can occur at any age | |||
| duration = Chronic | |||
| causes = Genetic mutations, [[B cell]] dysfunction | |||
| risks = Family history of [[immunodeficiency]] | |||
| diagnosis = [[Blood test]] measuring IgG levels | |||
| differential = [[Common variable immunodeficiency]], [[Selective IgA deficiency]] | |||
| treatment = [[Immunoglobulin replacement therapy]], [[antibiotics]] for infections | |||
| prognosis = Variable, depending on severity and treatment | |||
| frequency = Rare | |||
}} | |||
{{DISPLAYTITLE:IgG Deficiency}} | {{DISPLAYTITLE:IgG Deficiency}} | ||
'''IgG deficiency''' is a type of [[immunodeficiency]] disorder characterized by a lower than normal level of [[Immunoglobulin G|IgG]] antibodies in the blood. IgG is the most common type of antibody found in the circulation and plays a crucial role in the body's immune response by identifying and neutralizing pathogens such as bacteria and viruses. | '''IgG deficiency''' is a type of [[immunodeficiency]] disorder characterized by a lower than normal level of [[Immunoglobulin G|IgG]] antibodies in the blood. IgG is the most common type of antibody found in the circulation and plays a crucial role in the body's immune response by identifying and neutralizing pathogens such as bacteria and viruses. | ||
== Pathophysiology == | == Pathophysiology == | ||
IgG deficiency can result from a variety of causes, including genetic factors, certain medical conditions, and the use of specific medications. The deficiency leads to an increased susceptibility to infections, particularly those affecting the respiratory and gastrointestinal tracts. | IgG deficiency can result from a variety of causes, including genetic factors, certain medical conditions, and the use of specific medications. The deficiency leads to an increased susceptibility to infections, particularly those affecting the respiratory and gastrointestinal tracts. | ||
=== Genetic Causes === | === Genetic Causes === | ||
Some individuals may have a hereditary predisposition to IgG deficiency. Genetic mutations affecting the production or function of IgG can lead to this condition. | Some individuals may have a hereditary predisposition to IgG deficiency. Genetic mutations affecting the production or function of IgG can lead to this condition. | ||
=== Acquired Causes === | === Acquired Causes === | ||
IgG deficiency can also be acquired due to other medical conditions such as [[chronic lymphocytic leukemia]], [[multiple myeloma]], or [[HIV/AIDS]]. Certain medications, such as immunosuppressants, can also lead to reduced IgG levels. | IgG deficiency can also be acquired due to other medical conditions such as [[chronic lymphocytic leukemia]], [[multiple myeloma]], or [[HIV/AIDS]]. Certain medications, such as immunosuppressants, can also lead to reduced IgG levels. | ||
== Clinical Manifestations == | == Clinical Manifestations == | ||
Patients with IgG deficiency may experience recurrent infections, particularly [[sinusitis]], [[bronchitis]], and [[pneumonia]]. They may also suffer from chronic [[diarrhea]] and other gastrointestinal issues. In some cases, patients may develop [[autoimmune disorders]] due to the dysregulation of the immune system. | Patients with IgG deficiency may experience recurrent infections, particularly [[sinusitis]], [[bronchitis]], and [[pneumonia]]. They may also suffer from chronic [[diarrhea]] and other gastrointestinal issues. In some cases, patients may develop [[autoimmune disorders]] due to the dysregulation of the immune system. | ||
== Diagnosis == | == Diagnosis == | ||
The diagnosis of IgG deficiency is typically made through blood tests that measure the levels of immunoglobulins. A significantly lower level of IgG compared to normal ranges indicates a deficiency. Additional tests may be conducted to assess the function of the immune system and to identify any underlying causes. | The diagnosis of IgG deficiency is typically made through blood tests that measure the levels of immunoglobulins. A significantly lower level of IgG compared to normal ranges indicates a deficiency. Additional tests may be conducted to assess the function of the immune system and to identify any underlying causes. | ||
== Treatment == | == Treatment == | ||
Treatment for IgG deficiency often involves addressing the underlying cause, if known, and managing infections. Patients may receive [[immunoglobulin replacement therapy]] to boost their immune system. This therapy involves regular infusions of IgG to help prevent infections. | Treatment for IgG deficiency often involves addressing the underlying cause, if known, and managing infections. Patients may receive [[immunoglobulin replacement therapy]] to boost their immune system. This therapy involves regular infusions of IgG to help prevent infections. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for individuals with IgG deficiency varies depending on the severity of the deficiency and the presence of any underlying conditions. With appropriate management, many patients can lead relatively normal lives, although they may require ongoing treatment to prevent infections. | The prognosis for individuals with IgG deficiency varies depending on the severity of the deficiency and the presence of any underlying conditions. With appropriate management, many patients can lead relatively normal lives, although they may require ongoing treatment to prevent infections. | ||
== See also == | |||
== | |||
* [[Immunodeficiency]] | * [[Immunodeficiency]] | ||
* [[Immunoglobulin G]] | * [[Immunoglobulin G]] | ||
* [[Immunoglobulin replacement therapy]] | * [[Immunoglobulin replacement therapy]] | ||
* [[Autoimmune disorder]] | * [[Autoimmune disorder]] | ||
[[Category:Immunology]] | [[Category:Immunology]] | ||
[[Category:Immune system disorders]] | [[Category:Immune system disorders]] | ||
Latest revision as of 00:32, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| IgG deficiency | |
|---|---|
| |
| Synonyms | Immunoglobulin G deficiency |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Recurrent infections, particularly of the sinuses and lungs |
| Complications | Increased risk of autoimmune diseases |
| Onset | Can occur at any age |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic mutations, B cell dysfunction |
| Risks | Family history of immunodeficiency |
| Diagnosis | Blood test measuring IgG levels |
| Differential diagnosis | Common variable immunodeficiency, Selective IgA deficiency |
| Prevention | N/A |
| Treatment | Immunoglobulin replacement therapy, antibiotics for infections |
| Medication | N/A |
| Prognosis | Variable, depending on severity and treatment |
| Frequency | Rare |
| Deaths | N/A |
IgG deficiency is a type of immunodeficiency disorder characterized by a lower than normal level of IgG antibodies in the blood. IgG is the most common type of antibody found in the circulation and plays a crucial role in the body's immune response by identifying and neutralizing pathogens such as bacteria and viruses.
Pathophysiology[edit]
IgG deficiency can result from a variety of causes, including genetic factors, certain medical conditions, and the use of specific medications. The deficiency leads to an increased susceptibility to infections, particularly those affecting the respiratory and gastrointestinal tracts.
Genetic Causes[edit]
Some individuals may have a hereditary predisposition to IgG deficiency. Genetic mutations affecting the production or function of IgG can lead to this condition.
Acquired Causes[edit]
IgG deficiency can also be acquired due to other medical conditions such as chronic lymphocytic leukemia, multiple myeloma, or HIV/AIDS. Certain medications, such as immunosuppressants, can also lead to reduced IgG levels.
Clinical Manifestations[edit]
Patients with IgG deficiency may experience recurrent infections, particularly sinusitis, bronchitis, and pneumonia. They may also suffer from chronic diarrhea and other gastrointestinal issues. In some cases, patients may develop autoimmune disorders due to the dysregulation of the immune system.
Diagnosis[edit]
The diagnosis of IgG deficiency is typically made through blood tests that measure the levels of immunoglobulins. A significantly lower level of IgG compared to normal ranges indicates a deficiency. Additional tests may be conducted to assess the function of the immune system and to identify any underlying causes.
Treatment[edit]
Treatment for IgG deficiency often involves addressing the underlying cause, if known, and managing infections. Patients may receive immunoglobulin replacement therapy to boost their immune system. This therapy involves regular infusions of IgG to help prevent infections.
Prognosis[edit]
The prognosis for individuals with IgG deficiency varies depending on the severity of the deficiency and the presence of any underlying conditions. With appropriate management, many patients can lead relatively normal lives, although they may require ongoing treatment to prevent infections.
