AB-PICA: Difference between revisions

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== AB-PICA ==
== Anterior Inferior Cerebellar Artery (AICA) ==


'''AB-PICA''' is a synthetic cannabinoid that has been used in scientific research. It is a potent agonist of the [[cannabinoid receptor]]s, which are part of the [[endocannabinoid system]]. AB-PICA is structurally related to other synthetic cannabinoids and is often used in studies to understand the effects of cannabinoids on the human body.
[[File:AB-PICA_structure.png|thumb|right|Diagram of the cerebellar arteries, including the AICA.]]


=== Chemical Structure ===
The '''Anterior Inferior Cerebellar Artery''' (AICA) is a crucial artery in the [[human brain]] that supplies blood to the [[cerebellum]] and parts of the [[brainstem]]. It is one of the three main arteries that provide blood to the cerebellum, the others being the [[Superior Cerebellar Artery]] (SCA) and the [[Posterior Inferior Cerebellar Artery]] (PICA).


The chemical structure of AB-PICA is characterized by a core indole structure with a pentyl chain and an amide linkage. The full chemical name is N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indole-3-carboxamide. This structure allows it to bind effectively to cannabinoid receptors, mimicking the effects of naturally occurring cannabinoids such as [[tetrahydrocannabinol]] (THC).
== Anatomy ==


[[File:AB-PICA_structure.png|thumb|right|Chemical structure of AB-PICA]]
The AICA typically arises from the [[basilar artery]], which is a major blood vessel located at the base of the brain. The basilar artery itself is formed by the union of the two [[vertebral arteries]].


=== Pharmacology ===
=== Course ===


AB-PICA acts as a full agonist at the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors. These receptors are part of the [[G protein-coupled receptor]] family and are involved in a variety of physiological processes including pain sensation, mood regulation, and appetite.
The AICA travels laterally from its origin on the basilar artery, passing over the [[pons]] and the [[cerebellopontine angle]]. It then courses around the brainstem to reach the anterior inferior portion of the cerebellum.


The binding affinity of AB-PICA to these receptors is high, which contributes to its potent effects. The activation of CB1 receptors in the central nervous system is primarily responsible for the psychoactive effects associated with cannabinoids.
=== Branches ===


=== Legal Status ===
The AICA gives off several branches that supply the following structures:


The legal status of AB-PICA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. It is often included in legislation aimed at controlling synthetic cannabinoids and other novel psychoactive substances.
* The anterior inferior portion of the cerebellum
* The [[flocculus]], a small lobe of the cerebellum
* Parts of the [[pons]] and the [[medulla oblongata]]


=== Research and Applications ===
== Function ==


AB-PICA is primarily used in research settings to study the effects of synthetic cannabinoids on the body. It is used to investigate the [[endocannabinoid system]] and to develop potential therapeutic agents that target cannabinoid receptors.
The primary function of the AICA is to supply oxygenated blood to the regions of the brain it serves. This includes parts of the cerebellum, which is responsible for coordinating voluntary movements, balance, and posture, as well as parts of the brainstem, which control vital functions such as breathing and heart rate.


Research involving AB-PICA can provide insights into the treatment of conditions such as chronic pain, [[multiple sclerosis]], and [[epilepsy]], where modulation of the endocannabinoid system may be beneficial.
== Clinical Significance ==
 
[[File:AB-PICA_structure.png|thumb|left|Illustration showing the relationship of the AICA with other cerebellar arteries.]]
 
Occlusion or blockage of the AICA can lead to a type of [[stroke]] known as an AICA syndrome. Symptoms of AICA syndrome may include:
 
* [[Vertigo]]
* [[Hearing loss]]
* [[Facial paralysis]]
* [[Ataxia]], or lack of voluntary coordination of muscle movements
 
These symptoms occur due to the disruption of blood flow to the areas of the brain supplied by the AICA.


== Related Pages ==
== Related Pages ==
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]
* [[Endocannabinoid system]]
* [[Tetrahydrocannabinol]]


[[Category:Synthetic cannabinoids]]
* [[Cerebellum]]
* [[Basilar artery]]
* [[Vertebral artery]]
* [[Posterior Inferior Cerebellar Artery]]
* [[Superior Cerebellar Artery]]
 
[[Category:Arteries of the head and neck]]

Latest revision as of 03:41, 13 February 2025

Anterior Inferior Cerebellar Artery (AICA)[edit]

Diagram of the cerebellar arteries, including the AICA.

The Anterior Inferior Cerebellar Artery (AICA) is a crucial artery in the human brain that supplies blood to the cerebellum and parts of the brainstem. It is one of the three main arteries that provide blood to the cerebellum, the others being the Superior Cerebellar Artery (SCA) and the Posterior Inferior Cerebellar Artery (PICA).

Anatomy[edit]

The AICA typically arises from the basilar artery, which is a major blood vessel located at the base of the brain. The basilar artery itself is formed by the union of the two vertebral arteries.

Course[edit]

The AICA travels laterally from its origin on the basilar artery, passing over the pons and the cerebellopontine angle. It then courses around the brainstem to reach the anterior inferior portion of the cerebellum.

Branches[edit]

The AICA gives off several branches that supply the following structures:

Function[edit]

The primary function of the AICA is to supply oxygenated blood to the regions of the brain it serves. This includes parts of the cerebellum, which is responsible for coordinating voluntary movements, balance, and posture, as well as parts of the brainstem, which control vital functions such as breathing and heart rate.

Clinical Significance[edit]

Illustration showing the relationship of the AICA with other cerebellar arteries.

Occlusion or blockage of the AICA can lead to a type of stroke known as an AICA syndrome. Symptoms of AICA syndrome may include:

These symptoms occur due to the disruption of blood flow to the areas of the brain supplied by the AICA.

Related Pages[edit]

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