4-Aminophenol

An organic compound used in the synthesis of paracetamol

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4-Aminophenol is an organic compound with the formula C₆H₇NO. It is a derivative of phenol and is an important intermediate in the synthesis of various pharmaceuticals, including paracetamol.

Structure and Properties

4-Aminophenol consists of a phenolic ring with an amino group (NH₂) at the para position. This configuration gives it unique chemical properties, making it a useful compound in organic synthesis.

Synthesis

4-Aminophenol can be synthesized through several methods, including the reduction of nitrophenols. One common industrial method involves the reduction of 4-nitrophenol using hydrogen in the presence of a catalyst.

Applications

4-Aminophenol is primarily used in the production of paracetamol, a widely used analgesic and antipyretic. The synthesis of paracetamol from phenol involves the acetylation of 4-aminophenol.

Synthesis of Paracetamol

Synthesis of paracetamol from phenol

The synthesis of paracetamol from phenol involves several steps:

1. Nitration of phenol to form 4-nitrophenol. 2. Reduction of 4-nitrophenol to 4-aminophenol. 3. Acetylation of 4-aminophenol to form paracetamol.

Safety and Handling

4-Aminophenol should be handled with care, as it can be harmful if ingested or inhaled. It may cause irritation to the skin and eyes. Proper safety equipment, such as gloves and goggles, should be used when handling this compound.

Related Compounds

• Phenol
• Paracetamol
• 4-Nitrophenol

Related Pages

• Paracetamol
• Phenol
• Aminophenol

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4-Aminophenol

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  Synthesis of paracetamol from phenol