13-Hydroxyoctadecadienoic acid: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{DISPLAYTITLE:13-Hydroxyoctadecadienoic acid}} | {{DISPLAYTITLE:13-Hydroxyoctadecadienoic acid}} | ||
== 13-Hydroxyoctadecadienoic acid == | |||
[[File:13-HODE.svg|thumb|right|Chemical structure of 13-Hydroxyoctadecadienoic acid]] | |||
13-Hydroxyoctadecadienoic acid, commonly abbreviated as 13-HODE, is a type of [[hydroxy fatty acid]] derived from the oxidation of [[linoleic acid]]. It is one of the primary products formed during the enzymatic and non-enzymatic oxidation of linoleic acid, a common polyunsaturated fatty acid found in many vegetable oils. | |||
== | == Formation == | ||
13- | 13-HODE is formed through the action of [[lipoxygenase]] enzymes, which catalyze the oxidation of linoleic acid. This process involves the insertion of molecular oxygen into the fatty acid chain, resulting in the formation of a hydroperoxide intermediate. The hydroperoxide is then reduced to form 13-HODE. Non-enzymatic pathways, such as free radical oxidation, can also produce 13-HODE. | ||
==Biological Functions== | == Biological Functions == | ||
13-HODE | 13-HODE plays a role in various biological processes. It is involved in the regulation of [[inflammation]] and has been shown to have anti-inflammatory properties. Additionally, 13-HODE can influence [[cell signaling]] pathways and modulate the activity of [[nuclear receptors]] such as [[PPAR gamma]]. | ||
== | == Clinical Significance == | ||
The levels of 13-HODE in the body can be indicative of oxidative stress and inflammation. Elevated levels of 13-HODE have been associated with various pathological conditions, including [[atherosclerosis]], [[diabetes]], and certain types of [[cancer]]. As a result, 13-HODE is often studied as a potential biomarker for these diseases. | |||
== | == Related Compounds == | ||
13-HODE | 13-HODE is part of a larger family of oxidized fatty acids known as [[oxylipins]]. Other related compounds include 9-Hydroxyoctadecadienoic acid (9-HODE) and various [[prostaglandins]] and [[leukotrienes]]. These compounds collectively play important roles in the regulation of inflammation and immune responses. | ||
== Related Pages == | |||
==Related | |||
* [[Linoleic acid]] | * [[Linoleic acid]] | ||
* [[Lipoxygenase]] | * [[Lipoxygenase]] | ||
* [[ | * [[Oxidative stress]] | ||
* [[ | * [[Atherosclerosis]] | ||
* [[PPAR gamma]] | |||
[[Category:Fatty acids]] | [[Category:Fatty acids]] | ||
[[Category:Biochemistry]] | [[Category:Biochemistry]] | ||
[[Category: | [[Category:Oxylipins]] | ||
Latest revision as of 11:11, 15 February 2025
13-Hydroxyoctadecadienoic acid[edit]
13-Hydroxyoctadecadienoic acid, commonly abbreviated as 13-HODE, is a type of hydroxy fatty acid derived from the oxidation of linoleic acid. It is one of the primary products formed during the enzymatic and non-enzymatic oxidation of linoleic acid, a common polyunsaturated fatty acid found in many vegetable oils.
Formation[edit]
13-HODE is formed through the action of lipoxygenase enzymes, which catalyze the oxidation of linoleic acid. This process involves the insertion of molecular oxygen into the fatty acid chain, resulting in the formation of a hydroperoxide intermediate. The hydroperoxide is then reduced to form 13-HODE. Non-enzymatic pathways, such as free radical oxidation, can also produce 13-HODE.
Biological Functions[edit]
13-HODE plays a role in various biological processes. It is involved in the regulation of inflammation and has been shown to have anti-inflammatory properties. Additionally, 13-HODE can influence cell signaling pathways and modulate the activity of nuclear receptors such as PPAR gamma.
Clinical Significance[edit]
The levels of 13-HODE in the body can be indicative of oxidative stress and inflammation. Elevated levels of 13-HODE have been associated with various pathological conditions, including atherosclerosis, diabetes, and certain types of cancer. As a result, 13-HODE is often studied as a potential biomarker for these diseases.
Related Compounds[edit]
13-HODE is part of a larger family of oxidized fatty acids known as oxylipins. Other related compounds include 9-Hydroxyoctadecadienoic acid (9-HODE) and various prostaglandins and leukotrienes. These compounds collectively play important roles in the regulation of inflammation and immune responses.
