ADAM15: Difference between revisions
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{{ADAM family}} | |||
'''ADAM15''' (A Disintegrin and Metalloproteinase domain-containing protein 15) is a member of the ADAM family of proteins, which are known for their roles in cell signaling, adhesion, and proteolysis. ADAM15 is a type I transmembrane protein that is involved in various biological processes, including cell-cell interactions, cell-matrix interactions, and the shedding of membrane-bound proteins. | '''ADAM15''' (A Disintegrin and Metalloproteinase domain-containing protein 15) is a member of the ADAM family of proteins, which are known for their roles in cell signaling, adhesion, and proteolysis. ADAM15 is a type I transmembrane protein that is involved in various biological processes, including cell-cell interactions, cell-matrix interactions, and the shedding of membrane-bound proteins. | ||
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=== Function === | === Function === | ||
ADAM15 is involved in a variety of cellular processes, including: | ADAM15 is involved in a variety of cellular processes, including: | ||
* | * '''Cell adhesion''': The disintegrin domain of ADAM15 can interact with integrins, facilitating cell-cell and cell-matrix adhesion. | ||
* | * '''Proteolysis''': The metalloproteinase domain can cleave various substrates, including growth factors, cytokines, and cell surface receptors, modulating their activity. | ||
* | * '''Signal transduction''': ADAM15 can participate in signaling pathways that regulate cell proliferation, migration, and survival. | ||
=== Clinical Significance === | === Clinical Significance === | ||
ADAM15 has been implicated in several diseases, including: | ADAM15 has been implicated in several diseases, including: | ||
* | * '''Cancer''': Overexpression of ADAM15 has been observed in various cancers, such as breast, prostate, and colorectal cancer. It may contribute to tumor progression by promoting cell invasion and metastasis. | ||
* | * '''Arthritis''': ADAM15 is involved in the degradation of cartilage and may play a role in the pathogenesis of osteoarthritis and rheumatoid arthritis. | ||
* | * '''Cardiovascular diseases''': ADAM15 may be involved in the remodeling of blood vessels and the development of atherosclerosis. | ||
=== Research === | === Research === | ||
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* [[Cell adhesion]] | * [[Cell adhesion]] | ||
* [[Proteolysis]] | * [[Proteolysis]] | ||
{{Proteases}} | {{Proteases}} | ||
[[Category:Proteins]] | [[Category:Proteins]] | ||
[[Category:Enzymes]] | [[Category:Enzymes]] | ||
[[Category:Cell signaling]] | [[Category:Cell signaling]] | ||
Latest revision as of 02:30, 11 December 2024
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A Disintegrin and Metalloproteinase |
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ADAM15 (A Disintegrin and Metalloproteinase domain-containing protein 15) is a member of the ADAM family of proteins, which are known for their roles in cell signaling, adhesion, and proteolysis. ADAM15 is a type I transmembrane protein that is involved in various biological processes, including cell-cell interactions, cell-matrix interactions, and the shedding of membrane-bound proteins.
Structure[edit]
ADAM15 is composed of several distinct domains:
- A pro-domain, which is involved in the regulation of the protein's activity.
- A metalloproteinase domain, which has enzymatic activity and is responsible for the proteolytic cleavage of substrates.
- A disintegrin domain, which mediates interactions with integrins and other cell surface receptors.
- A cysteine-rich domain, which may play a role in protein-protein interactions.
- An EGF-like domain, which is involved in cell signaling.
- A transmembrane domain, which anchors the protein in the cell membrane.
- A cytoplasmic tail, which may be involved in intracellular signaling pathways.
Function[edit]
ADAM15 is involved in a variety of cellular processes, including:
- Cell adhesion: The disintegrin domain of ADAM15 can interact with integrins, facilitating cell-cell and cell-matrix adhesion.
- Proteolysis: The metalloproteinase domain can cleave various substrates, including growth factors, cytokines, and cell surface receptors, modulating their activity.
- Signal transduction: ADAM15 can participate in signaling pathways that regulate cell proliferation, migration, and survival.
Clinical Significance[edit]
ADAM15 has been implicated in several diseases, including:
- Cancer: Overexpression of ADAM15 has been observed in various cancers, such as breast, prostate, and colorectal cancer. It may contribute to tumor progression by promoting cell invasion and metastasis.
- Arthritis: ADAM15 is involved in the degradation of cartilage and may play a role in the pathogenesis of osteoarthritis and rheumatoid arthritis.
- Cardiovascular diseases: ADAM15 may be involved in the remodeling of blood vessels and the development of atherosclerosis.
Research[edit]
Ongoing research is focused on understanding the precise mechanisms by which ADAM15 contributes to disease and exploring its potential as a therapeutic target. Inhibitors of ADAM15's metalloproteinase activity are being investigated for their potential to treat cancer and inflammatory diseases.
Also see[edit]
| Hydrolase: proteases (EC 3.4) | ||||||
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