Cefpiramide: Difference between revisions

Latest revision as of 03:37, 13 February 2025

An article about the antibiotic Cefpiramide

Overview[edit]

Cefpiramide is a cephalosporin antibiotic used in the treatment of various bacterial infections. It belongs to the class of beta-lactam antibiotics, which are known for their broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Chemical Structure[edit]

Cefpiramide is characterized by its beta-lactam ring, which is essential for its antibacterial activity. The chemical structure of cefpiramide allows it to inhibit bacterial cell wall synthesis, leading to cell lysis and death.

Mechanism of Action[edit]

Cefpiramide works by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding inhibits the final transpeptidation step of peptidoglycan synthesis, which is crucial for bacterial cell wall integrity. As a result, the bacterium is unable to maintain its cell wall, leading to cell death.

Clinical Uses[edit]

Cefpiramide is used to treat a variety of infections, including:

Pharmacokinetics[edit]

Cefpiramide is administered via intravenous or intramuscular injection. It is well-distributed throughout the body and achieves therapeutic concentrations in various tissues and fluids. The drug is primarily excreted unchanged in the urine.

Side Effects[edit]

Common side effects of cefpiramide include:

Gastrointestinal disturbances such as nausea and diarrhea
Allergic reactions, including rash and anaphylaxis
Hematological effects such as eosinophilia and thrombocytopenia

Related pages[edit]

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-'''Cefpiramide''' is a third-generation [[cephalosporin]] antibiotic, developed for the treatment of severe bacterial infections. It is known for its broad-spectrum activity against both [[Gram-positive bacteria|Gram-positive]] and [[Gram-negative bacteria|Gram-negative]] bacteria, making it a valuable option in the clinical setting for treating infections where other antibiotics might fail. Cefpiramide's mechanism of action involves inhibiting bacterial cell wall synthesis, a common feature among cephalosporins, leading to bacterial cell death.
+{{Short description|An article about the antibiotic Cefpiramide}}
-==Medical Uses==
+==Overview==
-Cefpiramide is primarily used in the treatment of severe infections caused by susceptible strains of bacteria. These include infections of the respiratory tract, urinary tract, skin and soft tissue, and intra-abdominal infections. It is also used in the management of septicemia and meningitis. Due to its broad-spectrum activity, cefpiramide is often reserved for cases where other, less broad-spectrum antibiotics are ineffective or inappropriate.
+'''Cefpiramide''' is a [[cephalosporin]] [[antibiotic]] used in the treatment of various bacterial infections. It belongs to the class of [[beta-lactam antibiotics]], which are known for their broad-spectrum activity against [[Gram-positive bacteria|Gram-positive]] and [[Gram-negative bacteria]].
-==Pharmacology==
+==Chemical Structure==
-===Mechanism of Action===
+[[File:Cefpiramide.svg|thumb|right|Chemical structure of Cefpiramide]]
-Cefpiramide works by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall. By inhibiting these PBPs, cefpiramide disrupts the synthesis of the peptidoglycan layer of the bacterial cell wall, which is essential for cell wall integrity. As a result, the bacterial cell wall is weakened, leading to cell lysis and death.
+Cefpiramide is characterized by its beta-lactam ring, which is essential for its antibacterial activity. The chemical structure of cefpiramide allows it to inhibit bacterial cell wall synthesis, leading to cell lysis and death.
-===Pharmacokinetics===
+==Mechanism of Action==
-The pharmacokinetic profile of cefpiramide includes its absorption, distribution, metabolism, and excretion. After intravenous administration, cefpiramide is widely distributed throughout the body, including to tissues and fluids where infections are likely to occur. It is metabolized minimally in the body and is primarily excreted unchanged in the urine. This pharmacokinetic behavior ensures that effective concentrations of the drug are maintained at the site of infection for an adequate period.
+Cefpiramide works by binding to [[penicillin-binding proteins]] (PBPs) located inside the bacterial cell wall. This binding inhibits the final transpeptidation step of [[peptidoglycan]] synthesis, which is crucial for bacterial cell wall integrity. As a result, the bacterium is unable to maintain its cell wall, leading to cell death.
-==Adverse Effects==
+==Clinical Uses==
-Like all antibiotics, cefpiramide can cause side effects, although not everyone experiences them. Common adverse effects include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. Allergic reactions, ranging from rash to more severe forms like anaphylaxis, can occur. As with other cephalosporins, there is a potential for cross-reactivity in patients with a history of penicillin allergy.
+Cefpiramide is used to treat a variety of infections, including:
+* [[Respiratory tract infections]]
+* [[Urinary tract infections]]
+* [[Skin and soft tissue infections]]
+* [[Intra-abdominal infections]]
-==Resistance==
+==Pharmacokinetics==
-Bacterial resistance to cefpiramide can occur through various mechanisms, including the production of beta-lactamases that hydrolyze the antibiotic, alterations in PBPs that reduce drug binding, and changes in membrane permeability that decrease drug uptake. The development of resistance is a significant concern and underscores the importance of using cefpiramide judiciously, in accordance with antimicrobial stewardship principles.
+Cefpiramide is administered via [[intravenous]] or [[intramuscular]] injection. It is well-distributed throughout the body and achieves therapeutic concentrations in various tissues and fluids. The drug is primarily excreted unchanged in the urine.
-==Conclusion==
+==Side Effects==
-Cefpiramide is a valuable third-generation cephalosporin with a broad spectrum of activity against a wide range of bacterial pathogens. Its use is indicated in the treatment of severe bacterial infections, particularly those resistant to other antibiotics. However, the emergence of bacterial resistance highlights the need for careful use and ongoing research into new antimicrobial agents.
+Common side effects of cefpiramide include:
+* [[Gastrointestinal disturbances]] such as [[nausea]] and [[diarrhea]]
+* [[Allergic reactions]], including [[rash]] and [[anaphylaxis]]
+* [[Hematological effects]] such as [[eosinophilia]] and [[thrombocytopenia]]
+==Related pages==
+* [[Cephalosporin]]
+* [[Antibiotic]]
+* [[Beta-lactam antibiotic]]
-[[Category:Antibiotics]]
 [[Category:Cephalosporin antibiotics]]
-[[Category:Third-generation cephalosporins]]
+[[Category:Beta-lactam antibiotics]]
-{{medicine-stub}}