GRASP55: Difference between revisions

Latest revision as of 03:35, 13 February 2025

GRASP55[edit]

GRASP55 (Golgi Reassembly Stacking Protein of 55 kDa) is a protein that plays a crucial role in the Golgi apparatus structure and function. It is involved in the stacking of Golgi cisternae and is essential for maintaining the integrity of the Golgi structure during the cell cycle.

Structure[edit]

GRASP55 is characterized by its unique domain structure, which includes a PDZ domain and a GRASP domain. These domains are critical for its function in Golgi stacking and membrane tethering. The PDZ domain allows GRASP55 to interact with other proteins, while the GRASP domain is involved in membrane attachment.

Function[edit]

GRASP55 is primarily involved in the reassembly of the Golgi apparatus after mitosis. During cell division, the Golgi apparatus disassembles and then reassembles in the daughter cells. GRASP55, along with its homolog GRASP65, facilitates this reassembly process by mediating the stacking of Golgi cisternae.

Role in Golgi Apparatus[edit]

The Golgi apparatus is a central organelle in the secretory pathway of eukaryotic cells. It is responsible for modifying, sorting, and packaging proteins and lipids for secretion or delivery to other organelles. GRASP55 contributes to the structural organization of the Golgi by promoting the stacking of its cisternae, which is essential for its function.

Cellular Processes[edit]

GRASP55 is involved in various cellular processes beyond Golgi stacking. It plays a role in protein trafficking, cell signaling, and autophagy. Its function in autophagy is particularly important under stress conditions, where it helps in the formation of autophagosomes.

Interactions[edit]

GRASP55 interacts with several proteins, including GM130, a Golgi matrix protein, and Rab GTPases, which are involved in vesicle trafficking. These interactions are crucial for its role in Golgi reassembly and function.

Related pages[edit]

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-'''GRASP55''' ('''Golgi Reassembly Stacking Protein of 55 kDa''') is a protein that plays a crucial role in the structure and function of the [[Golgi apparatus]], an essential organelle in eukaryotic cells responsible for modifying, sorting, and packaging proteins and lipids for secretion or use within the cell. GRASP55 is part of the GRASP family of proteins, which also includes [[GRASP65]], with both proteins being involved in the maintenance of Golgi structure and the process of Golgi reassembly during the cell cycle.
+== GRASP55 ==
-== Function ==
+[[File:CnGRASP55domainsc.jpg|thumb|right|Diagram of GRASP55 domains]]
-GRASP55 is primarily located in the medial-Golgi cisternae and is involved in the stacking of Golgi cisternae and in the maintenance of the overall Golgi structure. It functions by forming oligomers that act as physical tethers, holding adjacent Golgi membranes together. This protein is also implicated in the process of [[Golgi reassembly]] following mitosis, a critical aspect of cell division. In addition to its structural role, GRASP55 has been implicated in various cellular processes including [[protein trafficking]], [[signal transduction]], and [[apoptosis]].
-== Structure ==
+'''GRASP55''' (Golgi Reassembly Stacking Protein of 55 kDa) is a protein that plays a crucial role in the [[Golgi apparatus]] structure and function. It is involved in the stacking of Golgi cisternae and is essential for maintaining the integrity of the Golgi structure during the cell cycle.
-The GRASP55 protein is characterized by a PDZ domain (a protein interaction domain) and a GRASP domain, which is involved in oligomerization and membrane stacking. The precise molecular mechanisms by which GRASP55 mediates Golgi stacking and interacts with other Golgi proteins are subjects of ongoing research.
-== Clinical Significance ==
+=== Structure ===
-Alterations in the expression or function of GRASP55 have been linked to various diseases, including [[cancer]] and [[neurodegenerative diseases]]. For example, overexpression of GRASP55 has been observed in certain types of cancer, where it may influence cancer cell proliferation and survival. Conversely, loss of GRASP55 function is being studied in the context of neurodegenerative diseases, where it may affect neuronal cell function and survival.
+GRASP55 is characterized by its unique domain structure, which includes a PDZ domain and a GRASP domain. These domains are critical for its function in Golgi stacking and membrane tethering. The PDZ domain allows GRASP55 to interact with other proteins, while the GRASP domain is involved in membrane attachment.
-== Research ==
+=== Function ===
-Research on GRASP55 is ongoing, with studies aimed at elucidating its precise roles in Golgi structure and function, its involvement in disease, and its potential as a target for therapeutic intervention. Understanding the molecular details of GRASP55's function could lead to new insights into the regulation of Golgi apparatus and novel therapeutic strategies for diseases associated with Golgi dysfunction.
+GRASP55 is primarily involved in the reassembly of the Golgi apparatus after mitosis. During cell division, the Golgi apparatus disassembles and then reassembles in the daughter cells. GRASP55, along with its homolog [[GRASP65]], facilitates this reassembly process by mediating the stacking of Golgi cisternae.
-== See Also ==
+=== Role in Golgi Apparatus ===
+The [[Golgi apparatus]] is a central organelle in the secretory pathway of eukaryotic cells. It is responsible for modifying, sorting, and packaging proteins and lipids for secretion or delivery to other organelles. GRASP55 contributes to the structural organization of the Golgi by promoting the stacking of its cisternae, which is essential for its function.
+=== Cellular Processes ===
+GRASP55 is involved in various cellular processes beyond Golgi stacking. It plays a role in [[protein trafficking]], [[cell signaling]], and [[autophagy]]. Its function in autophagy is particularly important under stress conditions, where it helps in the formation of autophagosomes.
+=== Interactions ===
+GRASP55 interacts with several proteins, including [[GM130]], a Golgi matrix protein, and [[Rab GTPases]], which are involved in vesicle trafficking. These interactions are crucial for its role in Golgi reassembly and function.
+== Related pages ==
 * [[Golgi apparatus]]
 * [[GRASP65]]
-* [[Cell cycle]]
 * [[Protein trafficking]]
+* [[Autophagy]]
 [[Category:Cell biology]]
 [[Category:Proteins]]
-{{Molecular-biology-stub}}