FHL3

FHL3 (Four and a half LIM domains 3) is a protein that in humans is encoded by the FHL3 gene. It is a member of the Four and a half LIM domains protein family, which is a group of proteins characterized by the presence of four LIM domains and an additional half LIM domain.

Function

FHL3 is a cytosolic protein that may be involved in specific cytoskeletal structures. This protein binds to the Rho family of GTPases, and may stimulate Rho-dependent signal transduction pathways. It is involved in the organization of actin filaments and in cell shape and motility.

Clinical significance

Mutations in the FHL3 gene have been associated with reducing the risk of developing muscular dystrophy, specifically X-linked recessive Emery-Dreifuss muscular dystrophy (EDMD).

See also

• Four and a half LIM domains protein
• Rho family of GTPases
• Emery-Dreifuss muscular dystrophy

References

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External links

• NCBI Gene
• UniProt

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