VU-0238429: Difference between revisions

Latest revision as of 10:59, 15 February 2025

Overview[edit]

VU-0238429 is a chemical compound that acts as a selective positive allosteric modulator of the metabotropic glutamate receptor subtype 4 (mGluR4). It is used primarily in scientific research to study the role of mGluR4 in the central nervous system and its potential therapeutic applications.

Chemical Properties[edit]

VU-0238429 is characterized by its specific chemical structure, which allows it to selectively modulate the activity of mGluR4. The compound's structure is depicted in the image to the right, highlighting its unique molecular configuration.

Mechanism of Action[edit]

VU-0238429 functions as a positive allosteric modulator, meaning it binds to a site on the mGluR4 receptor that is distinct from the orthosteric site where the endogenous ligand, glutamate, binds. This binding enhances the receptor's response to glutamate, thereby modulating neurotransmission in the brain.

Research Applications[edit]

Research involving VU-0238429 has focused on its potential therapeutic benefits in neurological disorders. By modulating mGluR4 activity, VU-0238429 may influence pathways involved in Parkinson's disease, anxiety disorders, and schizophrenia.

Pharmacological Effects[edit]

Studies have shown that VU-0238429 can produce anxiolytic and antipsychotic-like effects in animal models. These effects are attributed to its ability to enhance mGluR4-mediated neurotransmission, which may help in balancing excitatory and inhibitory signals in the brain.

Safety and Toxicology[edit]

As with many research chemicals, the safety profile of VU-0238429 is not fully established. It is primarily used in controlled laboratory settings, and its effects in humans are not well-documented.

Related Pages[edit]

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-'''VU-0238429''' is a [[chemical compound]] that is known for its role as a [[muscarinic acetylcholine receptor M1|M1 muscarinic acetylcholine receptor]] positive allosteric modulator. This compound is often used in [[pharmacology]] and [[neuroscience]] research.
+{{DISPLAYTITLE:VU-0238429}}
-==Chemistry==
+== Overview ==
-VU-0238429 is a synthetic compound. It is classified as a [[positive allosteric modulator]], which means it enhances the activity of the [[neurotransmitter]] acetylcholine at the M1 muscarinic acetylcholine receptor.
+[[File:VU0238429_structure.png|thumb|right|Chemical structure of VU-0238429]]
+'''VU-0238429''' is a chemical compound that acts as a selective positive allosteric modulator of the [[metabotropic glutamate receptor]] subtype 4 (mGluR4). It is used primarily in scientific research to study the role of mGluR4 in the central nervous system and its potential therapeutic applications.
-==Pharmacology==
+== Chemical Properties ==
-In pharmacology, VU-0238429 is used to study the M1 muscarinic acetylcholine receptor. This receptor is one of five muscarinic acetylcholine receptors (M1-M5) that are found in the [[central nervous system]] and peripheral tissues. The M1 receptor is predominantly found in the brain and is involved in cognitive functions such as learning and memory.
+VU-0238429 is characterized by its specific chemical structure, which allows it to selectively modulate the activity of mGluR4. The compound's structure is depicted in the image to the right, highlighting its unique molecular configuration.
-==Neuroscience==
+== Mechanism of Action ==
-In neuroscience research, VU-0238429 is used to investigate the role of the M1 receptor in various neurological and psychiatric disorders. These include [[Alzheimer's disease]], [[schizophrenia]], and [[Parkinson's disease]]. The compound's ability to enhance the activity of the M1 receptor makes it a valuable tool in studying these conditions.
+VU-0238429 functions as a positive allosteric modulator, meaning it binds to a site on the mGluR4 receptor that is distinct from the orthosteric site where the endogenous ligand, [[glutamate]], binds. This binding enhances the receptor's response to glutamate, thereby modulating neurotransmission in the brain.
-==Research Applications==
+== Research Applications ==
-VU-0238429 has been used in various research studies. For example, it has been used to investigate the potential therapeutic effects of enhancing M1 receptor activity in models of Alzheimer's disease and schizophrenia. It has also been used to study the role of the M1 receptor in the regulation of sleep and wakefulness.
+Research involving VU-0238429 has focused on its potential therapeutic benefits in neurological disorders. By modulating mGluR4 activity, VU-0238429 may influence pathways involved in [[Parkinson's disease]], [[anxiety disorders]], and [[schizophrenia]].
-==See Also==
+== Pharmacological Effects ==
-* [[Muscarinic acetylcholine receptor]]
+Studies have shown that VU-0238429 can produce anxiolytic and antipsychotic-like effects in animal models. These effects are attributed to its ability to enhance mGluR4-mediated neurotransmission, which may help in balancing excitatory and inhibitory signals in the brain.
-* [[Positive allosteric modulator]]
-* [[Neurotransmitter]]
+== Safety and Toxicology ==
-* [[Alzheimer's disease]]
+As with many research chemicals, the safety profile of VU-0238429 is not fully established. It is primarily used in controlled laboratory settings, and its effects in humans are not well-documented.
-* [[Schizophrenia]]
+== Related Pages ==
+* [[Metabotropic glutamate receptor]]
+* [[Allosteric modulator]]
+* [[Neurotransmission]]
 * [[Parkinson's disease]]
 [[Category:Chemical compounds]]
 [[Category:Pharmacology]]
-[[Category:Neuroscience]]
+[[Category:Research tools]]
-{{Chem-stub}}
-{{Pharma-stub}}
-{{Neuroscience-stub}}