Zalospirone: Difference between revisions

From WikiMD's Wellness Encyclopedia

CSV import
 
CSV import
 
Line 1: Line 1:
'''Zalospirone''' is a [[psychoactive drug]] and [[serotonin receptor agonist]] that was developed by [[Pfizer]] in the 1980s. It is a member of the [[azapirone]] class of drugs and is closely related to other azapirones like [[buspirone]] and [[ipsapirone]].
{{Short description|An encyclopedia article about the drug Zalospirone}}


== History ==
==Zalospirone==
[[File:Zalospirone.svg|thumb|right|Chemical structure of Zalospirone]]
'''Zalospirone''' is a drug that belongs to the class of [[azapirones]], which are known for their anxiolytic properties. It is primarily studied for its potential use in the treatment of [[anxiety disorders]].


Zalospirone was first synthesized by Pfizer in the 1980s as part of a series of azapirones, a class of drugs known for their anxiolytic (anti-anxiety) and antidepressant effects. Despite showing promise in early trials, zalospirone was never marketed.
==Pharmacology==
Zalospirone acts as a partial agonist at the [[5-HT1A receptor]], which is a subtype of the [[serotonin receptor]]. This action is thought to contribute to its anxiolytic effects. Unlike traditional [[benzodiazepines]], azapirones like zalospirone do not exhibit sedative or muscle relaxant properties, making them potentially useful for patients who need to avoid these side effects.


== Pharmacology ==
==Mechanism of Action==
The primary mechanism of action of zalospirone involves modulation of the serotonergic system. By partially activating the 5-HT1A receptors, zalospirone can help to stabilize mood and reduce anxiety. This mechanism is similar to that of other azapirones, such as [[buspirone]].


Zalospirone acts as a partial agonist at the [[5-HT1A receptor]], a subtype of the serotonin receptor. This action is believed to be responsible for its anxiolytic and antidepressant effects. Like other azapirones, zalospirone also has some affinity for the [[dopamine D2 receptor]], although this action is much weaker than its effect on the 5-HT1A receptor.
==Clinical Use==
While zalospirone has shown promise in preclinical studies, its clinical use is not widespread. Research is ongoing to determine its efficacy and safety profile compared to other anxiolytics. The development of zalospirone has been limited, and it is not currently approved for use in many countries.


== Clinical significance ==
==Side Effects==
 
Common side effects associated with azapirones, including zalospirone, may include dizziness, headache, and nausea. These side effects are generally mild compared to those of benzodiazepines.
While zalospirone was never marketed, it has been used in scientific research to study the role of the 5-HT1A receptor in anxiety and depression. Its close relation to other marketed azapirones like buspirone also makes it of interest in the study of this class of drugs.
 
== See also ==


==Related pages==
* [[Anxiety disorder]]
* [[Azapirone]]
* [[Azapirone]]
* [[5-HT1A receptor]]
* [[5-HT1A receptor]]
* [[Buspirone]]
* [[Buspirone]]
* [[Ipsapirone]]


[[Category:Psychoactive drugs]]
[[Category:Anxiolytics]]
[[Category:Serotonin receptor agonists]]
[[Category:Azapirones]]
[[Category:Pfizer products]]
[[Category:Abandoned drugs]]
{{pharma-stub}}

Latest revision as of 03:47, 13 February 2025

An encyclopedia article about the drug Zalospirone


Zalospirone[edit]

Chemical structure of Zalospirone

Zalospirone is a drug that belongs to the class of azapirones, which are known for their anxiolytic properties. It is primarily studied for its potential use in the treatment of anxiety disorders.

Pharmacology[edit]

Zalospirone acts as a partial agonist at the 5-HT1A receptor, which is a subtype of the serotonin receptor. This action is thought to contribute to its anxiolytic effects. Unlike traditional benzodiazepines, azapirones like zalospirone do not exhibit sedative or muscle relaxant properties, making them potentially useful for patients who need to avoid these side effects.

Mechanism of Action[edit]

The primary mechanism of action of zalospirone involves modulation of the serotonergic system. By partially activating the 5-HT1A receptors, zalospirone can help to stabilize mood and reduce anxiety. This mechanism is similar to that of other azapirones, such as buspirone.

Clinical Use[edit]

While zalospirone has shown promise in preclinical studies, its clinical use is not widespread. Research is ongoing to determine its efficacy and safety profile compared to other anxiolytics. The development of zalospirone has been limited, and it is not currently approved for use in many countries.

Side Effects[edit]

Common side effects associated with azapirones, including zalospirone, may include dizziness, headache, and nausea. These side effects are generally mild compared to those of benzodiazepines.

Related pages[edit]