JWH-302: Difference between revisions

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'''JWH-302''' is a synthetic cannabinoid from the naphthoylindole family, which acts as a full agonist at both the CB<sub>1</sub> and CB<sub>2</sub> cannabinoid receptors, with a moderate selectivity for CB<sub>2</sub>. It was discovered by and named after [[John W. Huffman]], an organic chemist at Clemson University.
{{DISPLAYTITLE:JWH-302}}


==Chemistry==
== JWH-302 ==
JWH-302 is part of the [[naphthoylindole]] family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as [[JWH-018]] and [[JWH-073]], but differs in the substitution on the indole ring. JWH-302 has a methoxy group at the 5-position of the indole ring, whereas JWH-018 has a naphthyl group and JWH-073 has a butyl chain.
[[File:JWH-302.svg|thumb|right|Chemical structure of JWH-302]]
'''JWH-302''' is a synthetic [[cannabinoid]] that acts as a potent agonist at the [[cannabinoid receptor]]s. It is part of the [[naphthoylindole]] family of compounds, which are known for their ability to mimic the effects of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]].


==Pharmacology==
== Chemical Properties ==
JWH-302 acts as a full agonist at both the CB<sub>1</sub> and CB<sub>2</sub> [[cannabinoid receptors]], with a moderate selectivity for CB<sub>2</sub>. The CB<sub>1</sub> receptor is primarily located in the brain and mediates the psychoactive effects of cannabinoids, while the CB<sub>2</sub> receptor is primarily found in the immune system and is involved in immune response and inflammation.
JWH-302 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The structure of JWH-302 includes a naphthalene group attached to an indole core, which is a common feature among compounds in this class. The presence of these groups contributes to its high affinity for cannabinoid receptors.


==Effects==
== Pharmacology ==
The effects of JWH-302 are similar to those of other synthetic cannabinoids and include [[euphoria]], relaxation, altered perception, and in some cases, hallucinations. However, due to its full agonist activity at the cannabinoid receptors, JWH-302 may have a higher potential for adverse effects and dependence compared to partial agonists like [[THC]], the main active component of cannabis.
JWH-302 acts as a full agonist at both the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors. These receptors are part of the [[endocannabinoid system]], which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation. The activation of these receptors by JWH-302 can lead to effects similar to those produced by natural cannabinoids.


==Legal Status==
== Legal Status ==
The legal status of JWH-302 varies by country and is often subject to change. In many countries, including the United States, it is classified as a controlled substance due to its potential for abuse and dependence.
Due to its potential for abuse and lack of medical use, JWH-302, like many other synthetic cannabinoids, has been subject to legal restrictions in various countries. It is often included in legislation aimed at controlling synthetic drugs and "designer drugs."


==See Also==
== Synthesis ==
The synthesis of JWH-302 involves the reaction of a naphthoyl chloride with an indole derivative. This process is similar to the synthesis of other naphthoylindoles and requires careful control of reaction conditions to ensure the desired product is obtained.
 
== Potential Effects and Risks ==
The effects of JWH-302 are similar to those of other synthetic cannabinoids, which can include euphoria, altered perception, and relaxation. However, the use of synthetic cannabinoids has been associated with adverse effects such as anxiety, paranoia, and in some cases, severe health complications. The variability in potency and purity of these compounds can increase the risk of overdose and other negative outcomes.
 
== Related Pages ==
* [[Synthetic cannabinoids]]
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]
* [[Cannabinoid receptor]]
* [[John W. Huffman]]
* [[Endocannabinoid system]]
* [[Naphthoylindole]]


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:Indoles]]
[[Category:Naphthoylindoles]]
[[Category:Psychoactive drugs]]
{{Psychoactive substance-stub}}
{{pharmacology-stub}}

Latest revision as of 04:04, 13 February 2025


JWH-302[edit]

Chemical structure of JWH-302

JWH-302 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Properties[edit]

JWH-302 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The structure of JWH-302 includes a naphthalene group attached to an indole core, which is a common feature among compounds in this class. The presence of these groups contributes to its high affinity for cannabinoid receptors.

Pharmacology[edit]

JWH-302 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation. The activation of these receptors by JWH-302 can lead to effects similar to those produced by natural cannabinoids.

Legal Status[edit]

Due to its potential for abuse and lack of medical use, JWH-302, like many other synthetic cannabinoids, has been subject to legal restrictions in various countries. It is often included in legislation aimed at controlling synthetic drugs and "designer drugs."

Synthesis[edit]

The synthesis of JWH-302 involves the reaction of a naphthoyl chloride with an indole derivative. This process is similar to the synthesis of other naphthoylindoles and requires careful control of reaction conditions to ensure the desired product is obtained.

Potential Effects and Risks[edit]

The effects of JWH-302 are similar to those of other synthetic cannabinoids, which can include euphoria, altered perception, and relaxation. However, the use of synthetic cannabinoids has been associated with adverse effects such as anxiety, paranoia, and in some cases, severe health complications. The variability in potency and purity of these compounds can increase the risk of overdose and other negative outcomes.

Related Pages[edit]