UniProt: Difference between revisions
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{{DISPLAYTITLE:UniProt}} | |||
== Overview == | == Overview == | ||
The UniProt | [[File:Uniprot-logo.img.svg|thumb|right|The UniProt logo]] | ||
'''UniProt''' (Universal Protein Resource) is a comprehensive, high-quality, and freely accessible database of protein sequence and functional information. It is a central hub for the collection of functional information on proteins, with accurate, consistent, and rich annotation. UniProt is a collaboration between the [[European Bioinformatics Institute]] (EBI), the [[Swiss Institute of Bioinformatics]] (SIB), and the [[Protein Information Resource]] (PIR). | |||
== | == History == | ||
UniProt | UniProt was created in 2002 by the merger of three major protein sequence databases: Swiss-Prot, TrEMBL, and PIR-PSD. The goal was to provide a single, centralized resource for protein sequence and functional information. | ||
== | == Components == | ||
UniProt consists of several components: | |||
* '''[[UniProtKB]]''' (UniProt Knowledgebase): The central database of protein sequences and functional information, which is divided into two sections: | |||
The | * '''[[Swiss-Prot]]''': A manually annotated and reviewed section. | ||
* '''[[TrEMBL]]''': A section that contains computationally analyzed records that await full manual annotation. | |||
* '''[[UniParc]]''' (UniProt Archive): A comprehensive and non-redundant database that contains most of the publicly available protein sequences in the world. | |||
* '''[[UniRef]]''' (UniProt Reference Clusters): Provides clustered sets of sequences from UniProtKB and selected UniParc records to obtain complete coverage of sequence space at several resolutions. | |||
== | == Features == | ||
* [[ | UniProt provides a wide range of features, including: | ||
* [[ | |||
* [[ | * Detailed [[protein sequence]] information. | ||
* [[ | * Functional annotations such as [[protein function]], [[enzyme]] activity, and [[biological process]] involvement. | ||
* Information on [[protein structure]], [[post-translational modification]]s, and [[protein-protein interaction]]s. | |||
* Cross-references to other databases, including [[genomic]] and [[proteomic]] resources. | |||
== Access and Tools == | |||
UniProt is accessible through its website, which provides a user-friendly interface for searching and retrieving data. It also offers various tools for sequence analysis, including: | |||
* '''BLAST''': For sequence similarity searching. | |||
* '''Align''': For multiple sequence alignment. | |||
* '''Retrieve/ID mapping''': For converting between different database identifiers. | |||
== Applications == | |||
UniProt is widely used in [[bioinformatics]], [[molecular biology]], and [[biomedical research]]. It supports a variety of applications, including: | |||
* [[Drug discovery]] and [[development]]. | |||
* [[Genomics]] and [[proteomics]] research. | |||
* [[Functional genomics]] studies. | |||
== | == Related pages == | ||
* [ | * [[Protein structure]] | ||
* [[Bioinformatics]] | |||
* [[Genomics]] | |||
* [[Proteomics]] | |||
[[Category:Protein | [[Category:Bioinformatics databases]] | ||
[[Category:Protein structure]] | |||
[[Category:Biological databases]] | [[Category:Biological databases]] | ||
Latest revision as of 03:41, 13 February 2025
Overview[edit]
UniProt (Universal Protein Resource) is a comprehensive, high-quality, and freely accessible database of protein sequence and functional information. It is a central hub for the collection of functional information on proteins, with accurate, consistent, and rich annotation. UniProt is a collaboration between the European Bioinformatics Institute (EBI), the Swiss Institute of Bioinformatics (SIB), and the Protein Information Resource (PIR).
History[edit]
UniProt was created in 2002 by the merger of three major protein sequence databases: Swiss-Prot, TrEMBL, and PIR-PSD. The goal was to provide a single, centralized resource for protein sequence and functional information.
Components[edit]
UniProt consists of several components:
- UniProtKB (UniProt Knowledgebase): The central database of protein sequences and functional information, which is divided into two sections:
* Swiss-Prot: A manually annotated and reviewed section. * TrEMBL: A section that contains computationally analyzed records that await full manual annotation.
- UniParc (UniProt Archive): A comprehensive and non-redundant database that contains most of the publicly available protein sequences in the world.
- UniRef (UniProt Reference Clusters): Provides clustered sets of sequences from UniProtKB and selected UniParc records to obtain complete coverage of sequence space at several resolutions.
Features[edit]
UniProt provides a wide range of features, including:
- Detailed protein sequence information.
- Functional annotations such as protein function, enzyme activity, and biological process involvement.
- Information on protein structure, post-translational modifications, and protein-protein interactions.
- Cross-references to other databases, including genomic and proteomic resources.
Access and Tools[edit]
UniProt is accessible through its website, which provides a user-friendly interface for searching and retrieving data. It also offers various tools for sequence analysis, including:
- BLAST: For sequence similarity searching.
- Align: For multiple sequence alignment.
- Retrieve/ID mapping: For converting between different database identifiers.
Applications[edit]
UniProt is widely used in bioinformatics, molecular biology, and biomedical research. It supports a variety of applications, including:
- Drug discovery and development.
- Genomics and proteomics research.
- Functional genomics studies.
