JWH-122: Difference between revisions

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'''JWH-122''' is a synthetic cannabinoid that is derived from naphthoylindole. It acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with a binding affinity of 0.69nM at CB1 and 1.2nM at CB2.
{{DISPLAYTITLE:JWH-122}}


==Chemistry==
== Overview ==
JWH-122 is a part of the [[JWH series]] of synthetic cannabinoids. It is structurally related to [[JWH-018]], with the only difference being the addition of a methyl group to the 4 position of the naphthoyl ring. This modification increases the potency of JWH-122 by approximately 5 times compared to JWH-018.
'''JWH-122''' is a synthetic cannabinoid that acts as a potent agonist of the [[cannabinoid receptor]]s. It is part of the [[naphthoylindole]] family of compounds and is used in scientific research to study the [[endocannabinoid system]].


==Pharmacology==
== Chemical Structure ==
JWH-122 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. The CB1 receptor is primarily located in the brain, and is responsible for the psychoactive effects of cannabinoids. The CB2 receptor is primarily located in the immune system, and is responsible for the immunomodulatory effects of cannabinoids.
[[File:JWH-122.svg|thumb|right|Chemical structure of JWH-122]]
JWH-122 has a chemical structure that includes a naphthoylindole core. The full chemical name is ''1-Pentyl-3-(4-methyl-1-naphthoyl)indole''. This structure is similar to other synthetic cannabinoids, such as [[JWH-018]] and [[JWH-073]], which also belong to the naphthoylindole class.


==Effects==
== Pharmacology ==
The effects of JWH-122 are similar to those of other synthetic cannabinoids and include [[euphoria]], [[relaxation]], [[perceptual alterations]], and [[cognitive impairment]]. However, JWH-122 is more potent than many other synthetic cannabinoids, and its use has been associated with a number of adverse effects including [[anxiety]], [[paranoia]], [[tachycardia]], and [[seizures]].
JWH-122 acts as a full agonist at both the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors. It has a higher affinity for the CB1 receptor, which is primarily found in the [[central nervous system]]. This receptor interaction is responsible for the psychoactive effects associated with cannabinoids.


==Legal status==
== Effects ==
JWH-122 is illegal in many countries, including the United States, where it is classified as a Schedule I controlled substance.
The effects of JWH-122 are similar to those of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]]. Users may experience altered perception, mood changes, and cognitive effects. However, as a synthetic compound, JWH-122 can have unpredictable and potentially severe side effects.


==See also==
== Legal Status ==
Due to its potential for abuse and lack of medical use, JWH-122 is classified as a controlled substance in many countries. It is often included in legislation targeting synthetic cannabinoids and "[[designer drug]]s."
 
== Research ==
JWH-122 is used in research to better understand the [[endocannabinoid system]] and the effects of cannabinoid receptor activation. Studies often focus on its binding affinity, efficacy, and potential therapeutic applications.
 
== Related pages ==
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]
* [[Endocannabinoid system]]
* [[JWH-018]]
* [[JWH-018]]
* [[JWH-073]]
* [[JWH-073]]
* [[JWH-200]]
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:Designer drugs]]
[[Category:Designer drugs]]
[[Category:JWH cannabinoids]]
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Latest revision as of 03:57, 13 February 2025


Overview[edit]

JWH-122 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of compounds and is used in scientific research to study the endocannabinoid system.

Chemical Structure[edit]

Chemical structure of JWH-122

JWH-122 has a chemical structure that includes a naphthoylindole core. The full chemical name is 1-Pentyl-3-(4-methyl-1-naphthoyl)indole. This structure is similar to other synthetic cannabinoids, such as JWH-018 and JWH-073, which also belong to the naphthoylindole class.

Pharmacology[edit]

JWH-122 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. It has a higher affinity for the CB1 receptor, which is primarily found in the central nervous system. This receptor interaction is responsible for the psychoactive effects associated with cannabinoids.

Effects[edit]

The effects of JWH-122 are similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. Users may experience altered perception, mood changes, and cognitive effects. However, as a synthetic compound, JWH-122 can have unpredictable and potentially severe side effects.

Legal Status[edit]

Due to its potential for abuse and lack of medical use, JWH-122 is classified as a controlled substance in many countries. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."

Research[edit]

JWH-122 is used in research to better understand the endocannabinoid system and the effects of cannabinoid receptor activation. Studies often focus on its binding affinity, efficacy, and potential therapeutic applications.

Related pages[edit]