IRF4

IRF4 (Interferon Regulatory Factor 4) is a protein that in humans is encoded by the IRF4 gene. It is a member of the interferon regulatory factors family of transcription factors, playing a crucial role in the regulation of immune responses.

Function

IRF4 is unique among the IRFs in its regulatory role in the immune system. It is critical for the differentiation and activation of T cells, B cells, and macrophages. In B cells, IRF4 interacts with PU.1 and Spi-B to control immunoglobulin class switch recombination and the expression of several B cell-specific genes.

Clinical significance

Mutations in the IRF4 gene have been associated with the development of various lymphomas, including multiple myeloma, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. It has also been implicated in leukemia and melanoma.

See also

• Interferon regulatory factors
• Transcription factor

References

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External links

• IRF4 at the National Center for Biotechnology Information

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