Mitomycin C

Mitomycin C is a chemotherapy agent derived from the bacteria Streptomyces caespitosus or Streptomyces lavendulae. It is a type of antibiotic that is particularly effective against cancer due to its ability to cross-link DNA, which prevents the DNA from separating, thereby inhibiting DNA synthesis and cell division.

History

Mitomycin C was first discovered in the 1950s by Japanese scientists studying Streptomyces bacteria. It was approved for medical use in the United States in 1974.

Medical Uses

Mitomycin C is used to treat various types of cancers, including stomach cancer, pancreatic cancer, and breast cancer. It is also used in ophthalmology to prevent the recurrence of corneal erosion and to treat pterygium.

Mechanism of Action

Mitomycin C works by cross-linking the DNA, which prevents the DNA from separating. This inhibits DNA synthesis and cell division, which are necessary for cancer cells to grow and multiply.

Side Effects

Common side effects of Mitomycin C include nausea, vomiting, loss of appetite, and hair loss. More serious side effects can include lung problems, kidney problems, and blood disorders.

See Also

• Chemotherapy
• DNA
• Cancer

References

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