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'''Kethoxal''' (3-ethoxy-1,1-dihydroxy-2-butanone) is an organic compound that has [[antiviral]] and [[anaplasmosis]] properties. It has been studied for its role in antiviral treatments and has applications in treating certain parasitic infections like [[anaplasmosis]], which is caused by bacteria in the genus *Anaplasma*.
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'''Kethoxal''' (3-ethoxy-1,1-dihydroxy-2-butanone) is an organic compound that has [[antiviral]] and [[anaplasmosis]] properties.<ref name=Elks >{{Cite book | title = The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies | author = J. Elks | publisher = Springer | date = 2014 | page = 510 | url = https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA510&lpg=PA510&dq=3-ethoxy-2-butanone&source=bl&ots=6IRmn0Wyrz&sig=ZLOjU9hOamJL4Jb1pp2AZ9Pwop8&hl=en&sa=X&ved=0CFIQ6AEwDGoVChMIkseJ2L77xgIVxdWACh1NQAYV#v=onepage&q=3-ethoxy-2-butanone&f=false}}</ref><ref>{{cite web | url = http://www.merriam-webster.com/medical/kethoxal | title = Kethoxal | publisher = Merriam-Webster}}</ref> It is also forms a stable covalent [[adduct]] with [[guanine]], which makes it useful for [[Nucleic acid structure determination#Kethoxal|nucleic acid structure determination]].<ref>{{cite journal | doi = 10.1021/bi00829a034 | title = Reaction of guanine with glyoxal, pyruvaldehyde, and kethoxal, and the structure of the acylguanines. Synthesis of N2-alkylguanines |author1=Robert Shapiro |author2=Bertram I. Cohen |author3=Shian-Jan Shiuey |author4=Hans Maurer | journal = Biochemistry | date = 1969 | volume = 8 | issue = 1 | pages = 238–245}}</ref>
It is commonly used in scientific research and has potential applications in pharmacological treatments due to its activity in inhibiting virus replication and providing therapeutic benefits in infections caused by certain pathogens.
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== Nucleic acid binding ==
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Kethoxal, as with other 1,2-di[[carbonyl]] compounds,<ref>{{cite journal |title= The Reaction of Guanine Derivatives with 1,2-Dicarbonyl Compounds |first1= Robert |last1= Shapiro |first2= John |last2= Hachmann |journal= Biochemistry |year= 1966 |volume= 5 |issue= 9 |pages= 2799–2807 |doi= 10.1021/bi00873a004 |pmid= 5961865 }}</ref> reacts with nucleic acids. It has high specificity for guanine it over other [[ribonucleotide]]s. In whole RNA, it reacts preferentially with guanine residues that are not involved in [[hydrogen-bond]]ing.<ref>{{cite journal |title= Kethoxal—A Potentially Useful Reagent for the Determination of Nucleotide Sequences in Single-Stranded Regions of Transfer Ribonucleic Acid |first1= Michael |last1= Litt |first2= Virginia |last2= Hancock |journal= Biochemistry |year= 1967 |volume= 6 |issue= 6 |pages= 1848–1854 |doi= 10.1021/bi00858a036 |pmid= 6035923 }}</ref><ref>{{cite journal |last= Staehelin |first= Matthys |year= 1959 |journal= Biochim. Biophys. Acta |volume= 31 |issue= 2 |pages= 448–454 |title= Inactivation of virus nucleic acid with glyoxal derivatives |doi=10.1016/0006-3002(59)90019-8|pmid= 13628672 }}</ref> It can thus be used to probe the interactions involved with the [[nucleic acid secondary structure|secondary structure]] and other binding interactions of RNA<ref>{{cite journal| last= Gopinath |first= S.C.B. |title= Mapping of RNA-protein interactions |journal= Analytica Chimica Acta |volume= 636 |pages= 117–128 |year= 2009 |doi= 10.1016/j.aca.2009.01.052 |pmid= 19264161 |issue= 2 }}</ref> and help with [[nucleic acid sequence]] analysis. The binding is [[Reversible reaction|reversible]], which allows the kethoxal to be removed and the original RNA recovered.
== References ==
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[[Category:Diols]]
[[Category:Diols]]
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[[Category:Ethers]]
[[Category:Antivirals]]
[[Category:Antivirals]]
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Latest revision as of 22:13, 1 April 2025
Kethoxal
Kethoxal (3-ethoxy-1,1-dihydroxy-2-butanone) is an organic compound that has antiviral and anaplasmosis properties. It has been studied for its role in antiviral treatments and has applications in treating certain parasitic infections like anaplasmosis, which is caused by bacteria in the genus *Anaplasma*.
It is commonly used in scientific research and has potential applications in pharmacological treatments due to its activity in inhibiting virus replication and providing therapeutic benefits in infections caused by certain pathogens.
