Cutaneous squamous-cell carcinoma: Difference between revisions

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{{SI}}
{{Infobox medical condition
| name            = Cutaneous squamous-cell carcinoma
| image          = [[File:Squamous_Cell_Carcinoma.jpg|250px]]
| caption        = Cutaneous squamous-cell carcinoma on the skin
| field          = [[Dermatology]]
| synonyms        = cSCC
| symptoms        = [[Skin lesion]], [[ulcer (dermatology)|ulcer]], [[scaly skin]]
| complications  = [[Metastasis]], [[local tissue destruction]]
| onset          = Typically in [[older adults]]
| duration        = [[Chronic (medicine)|Chronic]]
| causes          = [[Ultraviolet]] light exposure, [[immunosuppression]]
| risks          = [[Sun exposure]], [[fair skin]], [[history of skin cancer]]
| diagnosis      = [[Skin biopsy]]
| differential    = [[Basal-cell carcinoma]], [[melanoma]], [[actinic keratosis]]
| prevention      = [[Sun protection]], [[avoidance of tanning beds]]
| treatment      = [[Surgical excision]], [[Mohs surgery]], [[radiation therapy]]
| prognosis      = Generally good with treatment, but can be aggressive
| frequency      = Common
}}
'''Cutaneous squamous-cell carcinoma''' (cSCC) is a type of [[skin cancer]] that originates from the [[squamous cells]] in the [[epidermis]], the skin's outermost layer. It is the second most common type of skin cancer, following [[basal cell carcinoma]].
'''Cutaneous squamous-cell carcinoma''' (cSCC) is a type of [[skin cancer]] that originates from the [[squamous cells]] in the [[epidermis]], the skin's outermost layer. It is the second most common type of skin cancer, following [[basal cell carcinoma]].
== Causes ==
== Causes ==
The primary cause of cSCC is prolonged exposure to [[ultraviolet (UV) radiation]], either from the sun or from tanning beds. Other risk factors include having light-colored skin, a history of sunburns, a weakened immune system, and exposure to certain chemicals.
The primary cause of cSCC is prolonged exposure to [[ultraviolet (UV) radiation]], either from the sun or from tanning beds. Other risk factors include having light-colored skin, a history of sunburns, a weakened immune system, and exposure to certain chemicals.
== Symptoms ==
== Symptoms ==
cSCC often appears as a firm red nodule or a flat lesion with a scaly, crusted surface. It is most commonly found on areas of the body that are frequently exposed to the sun, such as the face, ears, neck, lips, and backs of the hands.
cSCC often appears as a firm red nodule or a flat lesion with a scaly, crusted surface. It is most commonly found on areas of the body that are frequently exposed to the sun, such as the face, ears, neck, lips, and backs of the hands.
== Diagnosis ==
== Diagnosis ==
Diagnosis of cSCC typically involves a [[skin biopsy]], in which a small sample of skin is removed and examined under a microscope. If cSCC is confirmed, additional tests may be performed to determine the stage of the cancer and whether it has spread to other parts of the body.
Diagnosis of cSCC typically involves a [[skin biopsy]], in which a small sample of skin is removed and examined under a microscope. If cSCC is confirmed, additional tests may be performed to determine the stage of the cancer and whether it has spread to other parts of the body.
== Treatment ==
== Treatment ==
Treatment options for cSCC depend on the size, location, and stage of the cancer, as well as the patient's overall health. Options may include surgery, radiation therapy, and topical medications. In some cases, a combination of treatments may be used.
Treatment options for cSCC depend on the size, location, and stage of the cancer, as well as the patient's overall health. Options may include surgery, radiation therapy, and topical medications. In some cases, a combination of treatments may be used.
== Prevention ==
== Prevention ==
Prevention strategies for cSCC include protecting the skin from the sun, avoiding tanning beds, and regularly checking the skin for signs of cancer.
Prevention strategies for cSCC include protecting the skin from the sun, avoiding tanning beds, and regularly checking the skin for signs of cancer.
 
== Gallery ==
<gallery>
File:Advanced squamous cell carcinoma scalp.jpg|Advanced squamous cell carcinoma of the scalp
File:Squamous cell carcinoma of scalp, excision specimen.jpg|Squamous cell carcinoma of scalp, excision specimen
File:Squamous Cell Carcinoma.png|Cutaneous squamous-cell carcinoma
File:Histopathology of squamous cell carcinoma in situ.jpg|Histopathology of squamous cell carcinoma in situ
File:Micrograph of squamous cell carcinoma in situ - 100x.jpg|Micrograph of squamous cell carcinoma in situ - 100x
File:Micrograph of squamous cell carcinoma in situ - 400x.jpg|Micrograph of squamous cell carcinoma in situ - 400x
File:Bowen disease (1).jpg|Bowen disease
File:Bowen disease (2).jpg|Bowen disease
File:Bowen disease (3).jpg|Bowen disease
File:Bowen disease (4).jpg|Bowen disease
File:Gross pathology of squamous cell carcinoma.jpg|Gross pathology of squamous cell carcinoma
</gallery>
== See also ==
== See also ==
* [[Skin cancer]]
* [[Skin cancer]]
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* [[Actinic keratosis]]
* [[Actinic keratosis]]
* [[Mohs surgery]]
* [[Mohs surgery]]
[[Category:Skin cancer]]
[[Category:Skin cancer]]
[[Category:Dermatology]]
[[Category:Dermatology]]
[[Category:Oncology]]
[[Category:Oncology]]
{{stub}}
{{stub}}

Latest revision as of 13:45, 5 April 2025

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
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Cutaneous squamous-cell carcinoma
File:Squamous Cell Carcinoma.jpg
Synonyms cSCC
Pronounce N/A
Specialty N/A
Symptoms Skin lesion, ulcer, scaly skin
Complications Metastasis, local tissue destruction
Onset Typically in older adults
Duration Chronic
Types N/A
Causes Ultraviolet light exposure, immunosuppression
Risks Sun exposure, fair skin, history of skin cancer
Diagnosis Skin biopsy
Differential diagnosis Basal-cell carcinoma, melanoma, actinic keratosis
Prevention Sun protection, avoidance of tanning beds
Treatment Surgical excision, Mohs surgery, radiation therapy
Medication N/A
Prognosis Generally good with treatment, but can be aggressive
Frequency Common
Deaths N/A


Cutaneous squamous-cell carcinoma (cSCC) is a type of skin cancer that originates from the squamous cells in the epidermis, the skin's outermost layer. It is the second most common type of skin cancer, following basal cell carcinoma.

Causes[edit]

The primary cause of cSCC is prolonged exposure to ultraviolet (UV) radiation, either from the sun or from tanning beds. Other risk factors include having light-colored skin, a history of sunburns, a weakened immune system, and exposure to certain chemicals.

Symptoms[edit]

cSCC often appears as a firm red nodule or a flat lesion with a scaly, crusted surface. It is most commonly found on areas of the body that are frequently exposed to the sun, such as the face, ears, neck, lips, and backs of the hands.

Diagnosis[edit]

Diagnosis of cSCC typically involves a skin biopsy, in which a small sample of skin is removed and examined under a microscope. If cSCC is confirmed, additional tests may be performed to determine the stage of the cancer and whether it has spread to other parts of the body.

Treatment[edit]

Treatment options for cSCC depend on the size, location, and stage of the cancer, as well as the patient's overall health. Options may include surgery, radiation therapy, and topical medications. In some cases, a combination of treatments may be used.

Prevention[edit]

Prevention strategies for cSCC include protecting the skin from the sun, avoiding tanning beds, and regularly checking the skin for signs of cancer.

Gallery[edit]

See also[edit]

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