Para-Iodoamphetamine

Para-Iodoamphetamine (PIA), also known as 4-Iodoamphetamine, is a research chemical of the phenethylamine and amphetamine chemical classes. It acts as a selective serotonin releasing agent and is also a MAO-A inhibitor. It was developed in the 1960s and has been used in scientific research, but has not been marketed for medical use.

Chemistry

PIA is a phenethylamine and amphetamine derivative. It is structurally related to amphetamine, but the alpha-methyl group of amphetamine is replaced by a para-iodo group.

Pharmacology

PIA acts as a selective serotonin releasing agent with weak effects on dopamine and norepinephrine transporters. However, it is also a potent inhibitor of monoamine oxidase A (MAO-A), an enzyme that breaks down monoamine neurotransmitters in the brain.

Research

PIA has been used in scientific research for its effects on the serotonin system. It has been used in studies investigating the role of serotonin in mood and behavior, as well as in studies of the serotonin system in the brain.

Safety

As a research chemical, PIA has not been thoroughly tested for safety in humans. It is not approved for medical use and should not be used outside of a research setting.

See also

• Amphetamine
• Phenethylamine
• Serotonin
• Monoamine oxidase A

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Para-Iodoamphetamine

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  Structure of para-Iodoamphetamine