Usual interstitial pneumonia: Difference between revisions
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== | {{SI}} | ||
{{Infobox medical condition | |||
[[File:CT_scan_in_usual_interstitial_pneumonia_(UIP).jpg|thumb|CT scan showing usual interstitial pneumonia]] | | name = Usual interstitial pneumonia | ||
[[File:UIP_(Usual_interstitial_pneumonia)-CT_scan.jpg|thumb|Another CT scan of usual interstitial pneumonia]] | | image = [[File:CT_scan_in_usual_interstitial_pneumonia_(UIP).jpg|250px]] | ||
[[File:UIPlungbiopsy.jpg|thumb|Lung biopsy showing usual interstitial pneumonia]] | | caption = CT scan showing usual interstitial pneumonia | ||
[[File:Honeycomb_change.jpg|thumb|Honeycomb change in usual interstitial pneumonia]] | | synonyms = UIP | ||
[[File:Fibroblast_focus.jpg|thumb|Fibroblast focus in usual interstitial pneumonia]] | | specialty = [[Pulmonology]] | ||
| symptoms = [[Shortness of breath]], [[dry cough]], [[fatigue (medical)|fatigue]] | |||
| complications = [[Pulmonary hypertension]], [[respiratory failure]] | |||
| onset = Typically in adults over 50 | |||
| duration = Chronic | |||
| causes = [[Idiopathic]], [[connective tissue disease]], [[asbestosis]], [[chronic hypersensitivity pneumonitis]] | |||
| risks = [[Smoking]], [[environmental exposure]], [[genetic predisposition]] | |||
| diagnosis = [[High-resolution computed tomography|HRCT]], [[lung biopsy]] | |||
| differential = [[Nonspecific interstitial pneumonia]], [[hypersensitivity pneumonitis]], [[sarcoidosis]] | |||
| treatment = [[Antifibrotic therapy]], [[oxygen therapy]], [[lung transplantation]] | |||
| prognosis = Variable, often poor | |||
| frequency = Rare | |||
}} | |||
[[File:CT_scan_in_usual_interstitial_pneumonia_(UIP).jpg|left|thumb|CT scan showing usual interstitial pneumonia]] | |||
[[File:UIP_(Usual_interstitial_pneumonia)-CT_scan.jpg|left|thumb|Another CT scan of usual interstitial pneumonia]] | |||
[[File:UIPlungbiopsy.jpg|left|thumb|Lung biopsy showing usual interstitial pneumonia]] | |||
[[File:Honeycomb_change.jpg|left|thumb|Honeycomb change in usual interstitial pneumonia]] | |||
[[File:Fibroblast_focus.jpg|left|thumb|Fibroblast focus in usual interstitial pneumonia]] | |||
'''Usual interstitial pneumonia''' (UIP) is a specific form of [[lung disease]] characterized by progressive scarring of both lungs. It is the most common form of [[idiopathic pulmonary fibrosis]] (IPF), a type of [[interstitial lung disease]]. | '''Usual interstitial pneumonia''' (UIP) is a specific form of [[lung disease]] characterized by progressive scarring of both lungs. It is the most common form of [[idiopathic pulmonary fibrosis]] (IPF), a type of [[interstitial lung disease]]. | ||
== Clinical Features == | == Clinical Features == | ||
Patients with UIP typically present with [[dyspnea]] (shortness of breath) and a persistent [[dry cough]]. The disease is more common in older adults, particularly those over the age of 50. Physical examination may reveal [[clubbing (medicine)|clubbing]] of the fingers and [[crackles]] on lung auscultation. | Patients with UIP typically present with [[dyspnea]] (shortness of breath) and a persistent [[dry cough]]. The disease is more common in older adults, particularly those over the age of 50. Physical examination may reveal [[clubbing (medicine)|clubbing]] of the fingers and [[crackles]] on lung auscultation. | ||
== Pathology == | == Pathology == | ||
The hallmark of UIP is the presence of patchy interstitial fibrosis, which is most pronounced in the subpleural and basal regions of the lungs. Histologically, UIP is characterized by the presence of fibroblastic foci, honeycomb change, and temporal heterogeneity of fibrosis. | The hallmark of UIP is the presence of patchy interstitial fibrosis, which is most pronounced in the subpleural and basal regions of the lungs. Histologically, UIP is characterized by the presence of fibroblastic foci, honeycomb change, and temporal heterogeneity of fibrosis. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of UIP is typically made through a combination of clinical, radiological, and pathological findings. High-resolution [[computed tomography]] (HRCT) scans of the chest are crucial for diagnosis, often showing a pattern of reticular opacities, traction bronchiectasis, and honeycombing. A lung biopsy may be performed to confirm the diagnosis. | Diagnosis of UIP is typically made through a combination of clinical, radiological, and pathological findings. High-resolution [[computed tomography]] (HRCT) scans of the chest are crucial for diagnosis, often showing a pattern of reticular opacities, traction bronchiectasis, and honeycombing. A lung biopsy may be performed to confirm the diagnosis. | ||
== Treatment == | == Treatment == | ||
There is no cure for UIP, and treatment is primarily supportive. [[Antifibrotic]] medications such as [[pirfenidone]] and [[nintedanib]] may slow disease progression. [[Lung transplantation]] is an option for eligible patients with advanced disease. | There is no cure for UIP, and treatment is primarily supportive. [[Antifibrotic]] medications such as [[pirfenidone]] and [[nintedanib]] may slow disease progression. [[Lung transplantation]] is an option for eligible patients with advanced disease. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for patients with UIP is generally poor, with a median survival of 3 to 5 years after diagnosis. The disease course is variable, with some patients experiencing rapid progression and others having a more indolent course. | The prognosis for patients with UIP is generally poor, with a median survival of 3 to 5 years after diagnosis. The disease course is variable, with some patients experiencing rapid progression and others having a more indolent course. | ||
== See also == | |||
== | |||
* [[Idiopathic pulmonary fibrosis]] | * [[Idiopathic pulmonary fibrosis]] | ||
* [[Interstitial lung disease]] | * [[Interstitial lung disease]] | ||
* [[Lung transplantation]] | * [[Lung transplantation]] | ||
{{Pulmonology}} | {{Pulmonology}} | ||
[[Category:Interstitial lung diseases]] | [[Category:Interstitial lung diseases]] | ||
[[Category:Pulmonary fibrosis]] | [[Category:Pulmonary fibrosis]] | ||
{{stub}} | |||
Latest revision as of 15:29, 13 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Usual interstitial pneumonia | |
|---|---|
.jpg)
| |
| Synonyms | UIP |
| Pronounce | N/A |
| Specialty | Pulmonology |
| Symptoms | Shortness of breath, dry cough, fatigue |
| Complications | Pulmonary hypertension, respiratory failure |
| Onset | Typically in adults over 50 |
| Duration | Chronic |
| Types | N/A |
| Causes | Idiopathic, connective tissue disease, asbestosis, chronic hypersensitivity pneumonitis |
| Risks | Smoking, environmental exposure, genetic predisposition |
| Diagnosis | HRCT, lung biopsy |
| Differential diagnosis | Nonspecific interstitial pneumonia, hypersensitivity pneumonitis, sarcoidosis |
| Prevention | N/A |
| Treatment | Antifibrotic therapy, oxygen therapy, lung transplantation |
| Medication | N/A |
| Prognosis | Variable, often poor |
| Frequency | Rare |
| Deaths | N/A |
-CT_scan.jpg)
Usual interstitial pneumonia (UIP) is a specific form of lung disease characterized by progressive scarring of both lungs. It is the most common form of idiopathic pulmonary fibrosis (IPF), a type of interstitial lung disease.
Clinical Features[edit]
Patients with UIP typically present with dyspnea (shortness of breath) and a persistent dry cough. The disease is more common in older adults, particularly those over the age of 50. Physical examination may reveal clubbing of the fingers and crackles on lung auscultation.
Pathology[edit]
The hallmark of UIP is the presence of patchy interstitial fibrosis, which is most pronounced in the subpleural and basal regions of the lungs. Histologically, UIP is characterized by the presence of fibroblastic foci, honeycomb change, and temporal heterogeneity of fibrosis.
Diagnosis[edit]
Diagnosis of UIP is typically made through a combination of clinical, radiological, and pathological findings. High-resolution computed tomography (HRCT) scans of the chest are crucial for diagnosis, often showing a pattern of reticular opacities, traction bronchiectasis, and honeycombing. A lung biopsy may be performed to confirm the diagnosis.
Treatment[edit]
There is no cure for UIP, and treatment is primarily supportive. Antifibrotic medications such as pirfenidone and nintedanib may slow disease progression. Lung transplantation is an option for eligible patients with advanced disease.
Prognosis[edit]
The prognosis for patients with UIP is generally poor, with a median survival of 3 to 5 years after diagnosis. The disease course is variable, with some patients experiencing rapid progression and others having a more indolent course.
See also[edit]
| Pulmonology topics | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
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