Peyronie's disease: Difference between revisions
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| medication = [[Collagenase clostridium histolyticum]], [[verapamil]], [[interferon]] | | medication = [[Collagenase clostridium histolyticum]], [[verapamil]], [[interferon]] | ||
| frequency = Affects about 1% to 23% of men | | frequency = Affects about 1% to 23% of men | ||
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'''Peyronie's disease''' is a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the [[penis]], leading to abnormal curvature during erection.<ref>{{Cite journal |last=Herati |first=AS |title=Peyronie's disease: etiology, medical, and surgical therapy |journal=The Journal of Sexual Medicine |volume=13 |issue=4 |pages=515-28 |year=2016 |doi=10.1016/j.jsxm.2016.01.014}}</ref> | '''Peyronie's disease''' is a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the [[penis]], leading to abnormal curvature during erection.<ref>{{Cite journal |last=Herati |first=AS |title=Peyronie's disease: etiology, medical, and surgical therapy |journal=The Journal of Sexual Medicine |volume=13 |issue=4 |pages=515-28 |year=2016 |doi=10.1016/j.jsxm.2016.01.014}}</ref> | ||
Latest revision as of 12:35, 12 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
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| Peyronie's disease | |
|---|---|
 | |
| Synonyms | Induratio penis plastica |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Penile pain, penile curvature, erectile dysfunction |
| Complications | Erectile dysfunction, emotional distress |
| Onset | Typically between 40 and 60 years of age |
| Duration | Can be chronic |
| Types | N/A |
| Causes | Connective tissue disorder, trauma |
| Risks | Genetic predisposition, age, diabetes, smoking |
| Diagnosis | Physical examination, ultrasound |
| Differential diagnosis | Penile fracture, urethral stricture |
| Prevention | N/A |
| Treatment | Medication, surgery, shockwave therapy |
| Medication | Collagenase clostridium histolyticum, verapamil, interferon |
| Prognosis | N/A |
| Frequency | Affects about 1% to 23% of men |
| Deaths | N/A |
Peyronie's disease is a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis, leading to abnormal curvature during erection.<ref>Herati, AS,
Peyronie's disease: etiology, medical, and surgical therapy, The Journal of Sexual Medicine, 2016, Vol. 13(Issue: 4), pp. 515-28, DOI: 10.1016/j.jsxm.2016.01.014,</ref>
Pathophysiology[edit]
Peyronie's disease results from fibrotic changes within the tunica albuginea, the connective tissue envelope of the erectile tissue of the penis. This fibrosis leads to penile curvature and sometimes pain during erections. The underlying cause is not fully understood, but it is thought to be related to trauma, genetic factors, and possibly certain health conditions such as Dupuytren's contracture.<ref>Hellstrom, WJ,
Peyronie's disease: etiology, medical, and surgical therapy, The Journal of Andrology, 2002, Vol. 23(Issue: 6), pp. 819-23, DOI: 10.1002/j.1939-4640.2002.tb02283.x,</ref>
Symptoms[edit]
The primary symptom of Peyronie's disease is penile deformity, which typically manifests as a significant bend or curve during erection. Other symptoms may include pain during erection, erectile dysfunction, and a palpable lump in the penis. In some cases, the deformity may make sexual intercourse difficult or impossible.<ref>Smith, JF,
Peyronie's disease: current management, The American Family Physician, 2007, Vol. 76(Issue: 3), pp. 417-22,</ref>
Diagnosis[edit]
The diagnosis of Peyronie's disease is typically based on physical examination, patient history, and sometimes ultrasound imaging. During physical examination, the characteristic penile deformity can often be observed, and the plaques may be palpable. Ultrasound may be used to better visualize the plaques.<ref>Mulhall, JP,
Peyronie's disease: diagnosis and medical management, The Journal of Sexual Medicine, 2010, Vol. 7(Issue: 2), pp. 526-40, DOI: 10.1111/j.1743-6109.2009.01615.x,</ref>
Treatment[edit]
Treatment for Peyronie's disease can be challenging and may include medical, non-surgical, and surgical options. Medical treatments include oral medications such as potassium para-aminobenzoate and colchicine, as well as injectable medications like verapamil and interferon injections. Non-surgical treatments include extracorporeal shock wave therapy (ESWT) and penile traction therapy. Surgical options are generally reserved for more severe cases and can involve plication procedures, plaque incision and grafting, or penile prosthesis implantation.<ref>Nelson, CJ,
The psychosocial impact of Peyronie's disease, The Journal of Sexual Medicine, 2013, Vol. 10(Issue: 4), pp. 1109-15, DOI: 10.1111/jsm.12060,</ref>
Epidemiology[edit]
Peyronie's disease primarily affects middle-aged and older men. Studies suggest that the prevalence of Peyronie's disease may be around 3-9% of men, but the true prevalence is likely to be higher due to underdiagnosis and underreporting.<ref>Sommer, F,
Peyronie's disease: epidemiology and presentation, The Journal of Sexual Medicine, 2010, Vol. 7(Issue: 1), pp. 17-25, DOI: 10.1111/j.1743-6109.2009.01625.x,</ref>
Prognosis[edit]
The course of Peyronie's disease varies among individuals. Some men experience progression of their penile curvature, while others may see improvement or stabilization without treatment. Pain during erections generally improves over time. Treatment can help to reduce the curvature and improve sexual function, but it may not completely correct the deformity.<ref>Levine, LA,
Peyronie's disease: surgical treatment, The Journal of Sexual Medicine, 2011, Vol. 8(Issue: 3), pp. 686-90, DOI: 10.1111/j.1743-6109.2010.02165.x,</ref>
Prevention[edit]
There is no known way to prevent Peyronie's disease. However, avoiding penile injury (e.g., rough sexual practices or sports injuries) may reduce the risk. Maintaining good overall health and managing any underlying medical conditions can also help to maintain penile health.<ref>Mulhall, JP,
Peyronie's disease: risk factors and association with other comorbidities, The Journal of Sexual Medicine, 2010, Vol. 7(Issue: 1), pp. 75-83, DOI: 10.1111/j.1743-6109.2009.01591.x,</ref>
Research[edit]
Ongoing research in Peyronie's disease includes studies to better understand the genetic and molecular mechanisms underlying the condition, as well as the development of new treatments.<ref>Gonzalez-Cadavid, NF,
Peyronie's disease: new genetic and pathophysiology findings, and a proposed model for the use of statins in treatment, The Journal of Sexual Medicine, 2015, Vol. 12(Issue: 5), pp. 1023-33, DOI: 10.1111/jsm.12884,</ref>
