IgG deficiency

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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IgG deficiency
File:IgG molecular surface.jpg
Synonyms	Immunoglobulin G deficiency
Pronounce	N/A
Specialty	N/A
Symptoms	Recurrent infections, particularly of the sinuses and lungs
Complications	Increased risk of autoimmune diseases
Onset	Can occur at any age
Duration	Chronic
Types	N/A
Causes	Genetic mutations, B cell dysfunction
Risks	Family history of immunodeficiency
Diagnosis	Blood test measuring IgG levels
Differential diagnosis	Common variable immunodeficiency, Selective IgA deficiency
Prevention	N/A
Treatment	Immunoglobulin replacement therapy, antibiotics for infections
Medication	N/A
Prognosis	Variable, depending on severity and treatment
Frequency	Rare
Deaths	N/A

IgG deficiency is a type of immunodeficiency disorder characterized by a lower than normal level of IgG antibodies in the blood. IgG is the most common type of antibody found in the circulation and plays a crucial role in the body's immune response by identifying and neutralizing pathogens such as bacteria and viruses.

Pathophysiology

IgG deficiency can result from a variety of causes, including genetic factors, certain medical conditions, and the use of specific medications. The deficiency leads to an increased susceptibility to infections, particularly those affecting the respiratory and gastrointestinal tracts.

Genetic Causes

Some individuals may have a hereditary predisposition to IgG deficiency. Genetic mutations affecting the production or function of IgG can lead to this condition.

Acquired Causes

IgG deficiency can also be acquired due to other medical conditions such as chronic lymphocytic leukemia, multiple myeloma, or HIV/AIDS. Certain medications, such as immunosuppressants, can also lead to reduced IgG levels.

Clinical Manifestations

Patients with IgG deficiency may experience recurrent infections, particularly sinusitis, bronchitis, and pneumonia. They may also suffer from chronic diarrhea and other gastrointestinal issues. In some cases, patients may develop autoimmune disorders due to the dysregulation of the immune system.

Diagnosis

The diagnosis of IgG deficiency is typically made through blood tests that measure the levels of immunoglobulins. A significantly lower level of IgG compared to normal ranges indicates a deficiency. Additional tests may be conducted to assess the function of the immune system and to identify any underlying causes.

Treatment

Treatment for IgG deficiency often involves addressing the underlying cause, if known, and managing infections. Patients may receive immunoglobulin replacement therapy to boost their immune system. This therapy involves regular infusions of IgG to help prevent infections.

Prognosis

The prognosis for individuals with IgG deficiency varies depending on the severity of the deficiency and the presence of any underlying conditions. With appropriate management, many patients can lead relatively normal lives, although they may require ongoing treatment to prevent infections.

See also

• Immunodeficiency
• Immunoglobulin G
• Immunoglobulin replacement therapy
• Autoimmune disorder