Hyperinsulinism: Difference between revisions
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{{Infobox medical condition | |||
| name = Hyperinsulinism | |||
| image = [[File:Insulin_struct.png|250px]] | |||
| caption = Structure of [[insulin]] | |||
| field = [[Endocrinology]] | |||
| synonyms = | |||
| symptoms = [[Hypoglycemia]], [[sweating]], [[tremor]], [[hunger]], [[confusion]], [[seizures]] | |||
| complications = [[Brain damage]], [[seizures]], [[coma]] | |||
| onset = | |||
| duration = | |||
| types = [[Congenital hyperinsulinism]], [[Acquired hyperinsulinism]] | |||
| causes = [[Genetic mutations]], [[insulinoma]], [[medications]] | |||
| risks = | |||
| diagnosis = [[Blood test]], [[imaging studies]] | |||
| differential = [[Insulinoma]], [[reactive hypoglycemia]], [[factitious hypoglycemia]] | |||
| prevention = | |||
| treatment = [[Diazoxide]], [[octreotide]], [[surgery]] | |||
| medication = | |||
| prognosis = | |||
| frequency = | |||
}} | |||
{{Short description|A condition characterized by excessive insulin levels in the blood}} | {{Short description|A condition characterized by excessive insulin levels in the blood}} | ||
'''Hyperinsulinism''' is a condition characterized by an excess of [[insulin]] in the [[bloodstream]]. This condition can lead to various metabolic disturbances, primarily affecting the regulation of [[blood glucose]] levels. Hyperinsulinism can be caused by several factors, including [[insulinoma]], [[congenital hyperinsulinism]], and [[reactive hypoglycemia]]. | '''Hyperinsulinism''' is a condition characterized by an excess of [[insulin]] in the [[bloodstream]]. This condition can lead to various metabolic disturbances, primarily affecting the regulation of [[blood glucose]] levels. Hyperinsulinism can be caused by several factors, including [[insulinoma]], [[congenital hyperinsulinism]], and [[reactive hypoglycemia]]. | ||
==Pathophysiology== | ==Pathophysiology== | ||
Hyperinsulinism occurs when there is an overproduction of insulin by the [[pancreas]], or when the body's tissues are overly sensitive to insulin. Insulin is a hormone produced by the [[beta cells]] of the [[islets of Langerhans]] in the pancreas. It plays a crucial role in regulating blood glucose levels by facilitating the uptake of glucose into cells for energy production or storage as [[glycogen]]. | Hyperinsulinism occurs when there is an overproduction of insulin by the [[pancreas]], or when the body's tissues are overly sensitive to insulin. Insulin is a hormone produced by the [[beta cells]] of the [[islets of Langerhans]] in the pancreas. It plays a crucial role in regulating blood glucose levels by facilitating the uptake of glucose into cells for energy production or storage as [[glycogen]]. | ||
In hyperinsulinism, the excessive insulin levels cause blood glucose to be taken up by cells at a higher rate than normal, leading to [[hypoglycemia]], or low blood sugar levels. This can result in symptoms such as [[dizziness]], [[sweating]], [[confusion]], and in severe cases, [[seizures]] or [[coma]]. | In hyperinsulinism, the excessive insulin levels cause blood glucose to be taken up by cells at a higher rate than normal, leading to [[hypoglycemia]], or low blood sugar levels. This can result in symptoms such as [[dizziness]], [[sweating]], [[confusion]], and in severe cases, [[seizures]] or [[coma]]. | ||
==Causes== | ==Causes== | ||
There are several causes of hyperinsulinism, including: | There are several causes of hyperinsulinism, including: | ||
* '''Insulinoma''': A rare tumor of the pancreas that secretes insulin. | * '''Insulinoma''': A rare tumor of the pancreas that secretes insulin. | ||
* '''Congenital hyperinsulinism''': A genetic disorder where the beta cells produce too much insulin. | * '''Congenital hyperinsulinism''': A genetic disorder where the beta cells produce too much insulin. | ||
* '''Reactive hypoglycemia''': A condition where insulin is overproduced in response to a meal, leading to low blood sugar levels. | * '''Reactive hypoglycemia''': A condition where insulin is overproduced in response to a meal, leading to low blood sugar levels. | ||
* '''Medications''': Certain medications, such as [[sulfonylureas]], can cause increased insulin production. | * '''Medications''': Certain medications, such as [[sulfonylureas]], can cause increased insulin production. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of hyperinsulinism involves measuring blood insulin and glucose levels. A fasting test may be conducted to observe the body's insulin response when no food is consumed. Imaging studies, such as [[CT scan]] or [[MRI]], may be used to identify insulinomas or other pancreatic abnormalities. | The diagnosis of hyperinsulinism involves measuring blood insulin and glucose levels. A fasting test may be conducted to observe the body's insulin response when no food is consumed. Imaging studies, such as [[CT scan]] or [[MRI]], may be used to identify insulinomas or other pancreatic abnormalities. | ||
==Treatment== | ==Treatment== | ||
Treatment of hyperinsulinism depends on the underlying cause. Options include: | Treatment of hyperinsulinism depends on the underlying cause. Options include: | ||
* '''Surgical removal''': In cases of insulinoma, surgical removal of the tumor is often necessary. | * '''Surgical removal''': In cases of insulinoma, surgical removal of the tumor is often necessary. | ||
* '''Dietary management''': Frequent small meals and a diet low in simple carbohydrates can help manage symptoms. | * '''Dietary management''': Frequent small meals and a diet low in simple carbohydrates can help manage symptoms. | ||
* '''Medications''': Drugs such as [[diazoxide]] or [[octreotide]] may be used to reduce insulin secretion. | * '''Medications''': Drugs such as [[diazoxide]] or [[octreotide]] may be used to reduce insulin secretion. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for individuals with hyperinsulinism varies depending on the cause and the effectiveness of treatment. With appropriate management, many individuals can lead normal lives, although ongoing monitoring and treatment may be necessary. | The prognosis for individuals with hyperinsulinism varies depending on the cause and the effectiveness of treatment. With appropriate management, many individuals can lead normal lives, although ongoing monitoring and treatment may be necessary. | ||
==See also== | |||
== | |||
* [[Insulin]] | * [[Insulin]] | ||
* [[Hypoglycemia]] | * [[Hypoglycemia]] | ||
* [[Pancreas]] | * [[Pancreas]] | ||
* [[Endocrinology]] | * [[Endocrinology]] | ||
[[Category:Endocrine diseases]] | [[Category:Endocrine diseases]] | ||
[[Category:Metabolic disorders]] | [[Category:Metabolic disorders]] | ||
Latest revision as of 03:44, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Hyperinsulinism | |
|---|---|
| |
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Hypoglycemia, sweating, tremor, hunger, confusion, seizures |
| Complications | Brain damage, seizures, coma |
| Onset | |
| Duration | |
| Types | Congenital hyperinsulinism, Acquired hyperinsulinism |
| Causes | Genetic mutations, insulinoma, medications |
| Risks | |
| Diagnosis | Blood test, imaging studies |
| Differential diagnosis | Insulinoma, reactive hypoglycemia, factitious hypoglycemia |
| Prevention | |
| Treatment | Diazoxide, octreotide, surgery |
| Medication | |
| Prognosis | |
| Frequency | |
| Deaths | N/A |
A condition characterized by excessive insulin levels in the blood
Hyperinsulinism is a condition characterized by an excess of insulin in the bloodstream. This condition can lead to various metabolic disturbances, primarily affecting the regulation of blood glucose levels. Hyperinsulinism can be caused by several factors, including insulinoma, congenital hyperinsulinism, and reactive hypoglycemia.
Pathophysiology[edit]
Hyperinsulinism occurs when there is an overproduction of insulin by the pancreas, or when the body's tissues are overly sensitive to insulin. Insulin is a hormone produced by the beta cells of the islets of Langerhans in the pancreas. It plays a crucial role in regulating blood glucose levels by facilitating the uptake of glucose into cells for energy production or storage as glycogen. In hyperinsulinism, the excessive insulin levels cause blood glucose to be taken up by cells at a higher rate than normal, leading to hypoglycemia, or low blood sugar levels. This can result in symptoms such as dizziness, sweating, confusion, and in severe cases, seizures or coma.
Causes[edit]
There are several causes of hyperinsulinism, including:
- Insulinoma: A rare tumor of the pancreas that secretes insulin.
- Congenital hyperinsulinism: A genetic disorder where the beta cells produce too much insulin.
- Reactive hypoglycemia: A condition where insulin is overproduced in response to a meal, leading to low blood sugar levels.
- Medications: Certain medications, such as sulfonylureas, can cause increased insulin production.
Diagnosis[edit]
The diagnosis of hyperinsulinism involves measuring blood insulin and glucose levels. A fasting test may be conducted to observe the body's insulin response when no food is consumed. Imaging studies, such as CT scan or MRI, may be used to identify insulinomas or other pancreatic abnormalities.
Treatment[edit]
Treatment of hyperinsulinism depends on the underlying cause. Options include:
- Surgical removal: In cases of insulinoma, surgical removal of the tumor is often necessary.
- Dietary management: Frequent small meals and a diet low in simple carbohydrates can help manage symptoms.
- Medications: Drugs such as diazoxide or octreotide may be used to reduce insulin secretion.
Prognosis[edit]
The prognosis for individuals with hyperinsulinism varies depending on the cause and the effectiveness of treatment. With appropriate management, many individuals can lead normal lives, although ongoing monitoring and treatment may be necessary.
