Dermatopathia pigmentosa reticularis: Difference between revisions
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{{SI}} | |||
{{Infobox medical condition | |||
| name = Dermatopathia pigmentosa reticularis | |||
| image = [[File:Autosomal_dominant_-_en.svg|200px]] | |||
| image_size = 200px | |||
| alt = | |||
| caption = Dermatopathia pigmentosa reticularis is inherited in an [[autosomal dominant]] pattern. | |||
| synonyms = | |||
| pronounce = | |||
| specialty = [[Dermatology]], [[Genetics]] | |||
| symptoms = [[Reticulate pigmentation]], [[alopecia]], [[nail dystrophy]] | |||
| onset = | |||
| duration = | |||
| types = | |||
| causes = Mutations in the [[KRT14]] gene | |||
| risks = | |||
| diagnosis = [[Clinical diagnosis]], [[genetic testing]] | |||
| differential = | |||
| prevention = | |||
| treatment = [[Symptomatic treatment]] | |||
| medication = | |||
| prognosis = | |||
| frequency = Rare | |||
| deaths = | |||
}} | |||
'''Dermatopathia pigmentosa reticularis''' is a rare, genetic skin disorder characterized by hyperpigmentation, noncicatricial alopecia, and nail dystrophy. It is a form of [[Ectodermal dysplasia]], a group of conditions which primarily affect the skin, hair, nails, sweat glands, and teeth. | '''Dermatopathia pigmentosa reticularis''' is a rare, genetic skin disorder characterized by hyperpigmentation, noncicatricial alopecia, and nail dystrophy. It is a form of [[Ectodermal dysplasia]], a group of conditions which primarily affect the skin, hair, nails, sweat glands, and teeth. | ||
== Symptoms == | == Symptoms == | ||
The primary symptoms of Dermatopathia pigmentosa reticularis include: | The primary symptoms of Dermatopathia pigmentosa reticularis include: | ||
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* [[Noncicatricial alopecia]]: This refers to hair loss that does not lead to scarring. | * [[Noncicatricial alopecia]]: This refers to hair loss that does not lead to scarring. | ||
* [[Nail dystrophy]]: This is a condition characterized by the presence of abnormally shaped or sized nails. | * [[Nail dystrophy]]: This is a condition characterized by the presence of abnormally shaped or sized nails. | ||
== Causes == | == Causes == | ||
Dermatopathia pigmentosa reticularis is caused by mutations in the [[KRT14]] gene. This gene provides instructions for making a protein that is a crucial component of [[keratin]] intermediate filaments, which provide strength and resilience to skin cells. | Dermatopathia pigmentosa reticularis is caused by mutations in the [[KRT14]] gene. This gene provides instructions for making a protein that is a crucial component of [[keratin]] intermediate filaments, which provide strength and resilience to skin cells. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of Dermatopathia pigmentosa reticularis is based on the clinical symptoms and confirmed by genetic testing. The testing can identify mutations in the KRT14 gene. | Diagnosis of Dermatopathia pigmentosa reticularis is based on the clinical symptoms and confirmed by genetic testing. The testing can identify mutations in the KRT14 gene. | ||
== Treatment == | == Treatment == | ||
There is currently no cure for Dermatopathia pigmentosa reticularis. Treatment is symptomatic and supportive, focusing on managing the individual symptoms and complications. | There is currently no cure for Dermatopathia pigmentosa reticularis. Treatment is symptomatic and supportive, focusing on managing the individual symptoms and complications. | ||
== See also == | == See also == | ||
* [[Ectodermal dysplasia]] | * [[Ectodermal dysplasia]] | ||
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* [[Noncicatricial alopecia]] | * [[Noncicatricial alopecia]] | ||
* [[Nail dystrophy]] | * [[Nail dystrophy]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Skin conditions]] | [[Category:Skin conditions]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 18:10, 5 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Dermatopathia pigmentosa reticularis | |
|---|---|
| |
| Synonyms | |
| Pronounce | |
| Specialty | Dermatology, Genetics |
| Symptoms | Reticulate pigmentation, alopecia, nail dystrophy |
| Complications | N/A |
| Onset | |
| Duration | |
| Types | |
| Causes | Mutations in the KRT14 gene |
| Risks | |
| Diagnosis | Clinical diagnosis, genetic testing |
| Differential diagnosis | |
| Prevention | |
| Treatment | Symptomatic treatment |
| Medication | |
| Prognosis | |
| Frequency | Rare |
| Deaths | |
Dermatopathia pigmentosa reticularis is a rare, genetic skin disorder characterized by hyperpigmentation, noncicatricial alopecia, and nail dystrophy. It is a form of Ectodermal dysplasia, a group of conditions which primarily affect the skin, hair, nails, sweat glands, and teeth.
Symptoms[edit]
The primary symptoms of Dermatopathia pigmentosa reticularis include:
- Hyperpigmentation: This is a condition where patches of skin become darker in color than the normal surrounding skin.
- Noncicatricial alopecia: This refers to hair loss that does not lead to scarring.
- Nail dystrophy: This is a condition characterized by the presence of abnormally shaped or sized nails.
Causes[edit]
Dermatopathia pigmentosa reticularis is caused by mutations in the KRT14 gene. This gene provides instructions for making a protein that is a crucial component of keratin intermediate filaments, which provide strength and resilience to skin cells.
Diagnosis[edit]
Diagnosis of Dermatopathia pigmentosa reticularis is based on the clinical symptoms and confirmed by genetic testing. The testing can identify mutations in the KRT14 gene.
Treatment[edit]
There is currently no cure for Dermatopathia pigmentosa reticularis. Treatment is symptomatic and supportive, focusing on managing the individual symptoms and complications.
See also[edit]
References[edit]
<references />
