Lortalamine: Difference between revisions

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'''Lortalamine''' is an [[antidepressant]] that was developed in the 1980s but was never marketed. It is a [[serotonin-norepinephrine reuptake inhibitor]] (SNRI) and is structurally related to other antidepressants such as [[venlafaxine]] and [[desvenlafaxine]].
{{Short description|Overview of the chemical compound Lortalamine}}


== History ==
'''Lortalamine''' is a chemical compound that has been studied for its potential use in various medical applications. It is classified as a [[stimulant]] and has been the subject of research due to its effects on the central nervous system.
Lortalamine was developed in the 1980s by the pharmaceutical company [[Upjohn]]. Despite showing promise in early clinical trials, the drug was never marketed. The reasons for this are unclear, but it may have been due to the emergence of other, more effective antidepressants around the same time.


== Pharmacology ==
==Chemical Structure==
Lortalamine is a serotonin-norepinephrine reuptake inhibitor (SNRI). This means it works by increasing the levels of the neurotransmitters [[serotonin]] and [[norepinephrine]] in the brain, which can help to improve mood and relieve symptoms of depression.
[[File:Lortalamine.svg|thumb|right|Chemical structure of Lortalamine]]
Lortalamine is characterized by its unique chemical structure, which includes a combination of aromatic rings and amine groups. The presence of these functional groups contributes to its pharmacological activity.


== Structure ==
==Pharmacology==
Lortalamine is structurally related to other antidepressants such as venlafaxine and desvenlafaxine. These drugs are all part of the same class of medications, known as SNRIs.
Lortalamine acts primarily as a central nervous system stimulant. It is believed to increase the levels of certain neurotransmitters in the brain, such as [[dopamine]] and [[norepinephrine]], which leads to increased alertness and energy. This mechanism of action is similar to other stimulants, making it a compound of interest for further research.


== Clinical Trials ==
==Potential Uses==
Early clinical trials of lortalamine showed that it had potential as an antidepressant. However, for reasons that are not entirely clear, the drug was never marketed.
Research into Lortalamine has explored its potential use in treating conditions such as [[attention deficit hyperactivity disorder]] (ADHD) and [[narcolepsy]]. However, its efficacy and safety profile are still under investigation, and it is not currently approved for medical use.


== See Also ==
==Synthesis==
* [[Antidepressant]]
The synthesis of Lortalamine involves several steps, starting with the preparation of the aromatic ring system, followed by the introduction of the amine group. The process requires careful control of reaction conditions to ensure the correct formation of the desired product.
* [[Serotonin-norepinephrine reuptake inhibitor]]
* [[Venlafaxine]]
* [[Desvenlafaxine]]


[[Category:Antidepressants]]
==Safety and Side Effects==
[[Category:Serotonin-norepinephrine reuptake inhibitors]]
As with many stimulants, Lortalamine may have side effects, including increased heart rate, elevated blood pressure, and potential for abuse. Long-term effects and safety in humans have not been fully established, necessitating further research.
[[Category:Abandoned drugs]]


{{stub}}
==Related Compounds==
Lortalamine is structurally related to other stimulant compounds, such as [[amphetamine]] and [[methylphenidate]]. These compounds share similar mechanisms of action but differ in their chemical structures and pharmacokinetic properties.


== Lortalamine ==
==Research and Development==
<gallery>
Ongoing research is focused on understanding the full pharmacological profile of Lortalamine, including its potential therapeutic benefits and risks. Studies are also exploring its metabolism and excretion in the body to better understand its pharmacokinetics.
File:Lortalamine.svg|Lortalamine chemical structure
 
File:Lortalamine_ball-and-stick_model.png|Lortalamine ball-and-stick model
==Related Pages==
</gallery>
* [[Stimulant]]
* [[Central nervous system]]
* [[Neurotransmitter]]
* [[Pharmacology]]
 
[[File:Lortalamine_ball-and-stick_model.png|thumb|left|Ball-and-stick model of Lortalamine]]
 
==See Also==
* [[Amphetamine]]
* [[Methylphenidate]]
* [[Attention deficit hyperactivity disorder]]
 
{{DEFAULTSORT:Lortalamine}}
[[Category:Stimulants]]
[[Category:Chemical compounds]]
[[Category:Experimental drugs]]

Latest revision as of 18:57, 23 March 2025

Overview of the chemical compound Lortalamine


Lortalamine is a chemical compound that has been studied for its potential use in various medical applications. It is classified as a stimulant and has been the subject of research due to its effects on the central nervous system.

Chemical Structure[edit]

Chemical structure of Lortalamine

Lortalamine is characterized by its unique chemical structure, which includes a combination of aromatic rings and amine groups. The presence of these functional groups contributes to its pharmacological activity.

Pharmacology[edit]

Lortalamine acts primarily as a central nervous system stimulant. It is believed to increase the levels of certain neurotransmitters in the brain, such as dopamine and norepinephrine, which leads to increased alertness and energy. This mechanism of action is similar to other stimulants, making it a compound of interest for further research.

Potential Uses[edit]

Research into Lortalamine has explored its potential use in treating conditions such as attention deficit hyperactivity disorder (ADHD) and narcolepsy. However, its efficacy and safety profile are still under investigation, and it is not currently approved for medical use.

Synthesis[edit]

The synthesis of Lortalamine involves several steps, starting with the preparation of the aromatic ring system, followed by the introduction of the amine group. The process requires careful control of reaction conditions to ensure the correct formation of the desired product.

Safety and Side Effects[edit]

As with many stimulants, Lortalamine may have side effects, including increased heart rate, elevated blood pressure, and potential for abuse. Long-term effects and safety in humans have not been fully established, necessitating further research.

Related Compounds[edit]

Lortalamine is structurally related to other stimulant compounds, such as amphetamine and methylphenidate. These compounds share similar mechanisms of action but differ in their chemical structures and pharmacokinetic properties.

Research and Development[edit]

Ongoing research is focused on understanding the full pharmacological profile of Lortalamine, including its potential therapeutic benefits and risks. Studies are also exploring its metabolism and excretion in the body to better understand its pharmacokinetics.

Related Pages[edit]

Ball-and-stick model of Lortalamine

See Also[edit]