CCR4

CCR4 is a gene that encodes a protein known as C-C chemokine receptor type 4. This protein is a member of the G protein-coupled receptor family and is involved in the immune response. The CCR4 protein is expressed on the surface of certain immune cells, including T cells and macrophages, and plays a role in their migration and function.

Function

The CCR4 gene provides instructions for making a protein that is part of the immune system. This protein is found on the surface of certain types of white blood cells. The CCR4 protein is involved in the immune response, helping to regulate the movement and activity of these cells.

Clinical significance

Mutations in the CCR4 gene have been associated with certain types of cancer, including cutaneous T-cell lymphoma and adult T-cell leukemia/lymphoma. In these cancers, the CCR4 protein may be overexpressed, leading to increased migration of cancerous cells and contributing to the spread of the disease.

Therapeutic use

Because of its role in cancer, the CCR4 protein is a potential target for cancer therapies. Drugs that block the activity of the CCR4 protein may help to slow the spread of cancer cells and improve patient outcomes.

See also

• Chemokine receptor
• G protein-coupled receptor
• T cell
• Macrophage

References

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