Aggrecanase: Difference between revisions
From WikiMD's Wellness Encyclopedia
CSV import |
No edit summary Tag: Manual revert |
| (One intermediate revision by the same user not shown) | |
(No difference)
| |
Latest revision as of 17:09, 18 March 2025
Aggrecanase is an enzyme in the connective tissue that plays an important role in the pathogenesis of arthritis and other connective tissue diseases.
Role of aggrecanases[edit]
Aggrecanases are extracellular proteolytic enzymes.
ADAMTS family[edit]
Aggrecanases belong to a group of protein cleaving enzymes called ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin Motifs) family.
Mechanism of action[edit]
Aggrecanases act on large proteoglycans known as aggrecans, which are components of connective tissues such as cartilage.
Clinical significance[edit]
The inappropriate activity of aggrecanase is a mechanism by which cartilage degradation occurs in diseases such as arthritis.
Types of aggrecanases[edit]
There are two forms of aggrecanase exist in humans: ADAMTS4 or aggrecanase-1[1] and ADAMTS5 or aggrecanase-2.
External links[edit]
| Proteases: metalloendopeptidases (EC 3.4.24) | ||||||
|---|---|---|---|---|---|---|
|
| Enzymes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
