ZNF34

ZNF34 (Zinc Finger Protein 34) is a protein that in humans is encoded by the ZNF34 gene. This protein is a member of the zinc finger family of proteins, which are regulatory proteins that can bind to DNA, RNA, protein and/or lipid substrates.

Function

ZNF34 is a transcription factor that can bind to DNA and regulate gene expression. It is involved in various biological processes, including cell differentiation, cell growth, apoptosis, immune responses, response to stress, and protein folding.

Structure

The ZNF34 protein contains a KRAB domain at the N-terminus and a C2H2-type zinc finger domain at the C-terminus. The KRAB domain is a protein-protein interaction module that can recruit chromatin-modifying complexes to specific genomic loci. The zinc finger domain is responsible for DNA binding.

Clinical Significance

Mutations in the ZNF34 gene have been associated with various diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. Further research is needed to fully understand the role of ZNF34 in these diseases.

See Also

• Zinc finger
• Transcription factor
• Gene expression
• Protein folding

References

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