ZNF143

ZNF143 is a gene that encodes a protein in humans. This protein is a member of the zinc finger protein family and is known to play a crucial role in transcriptional regulation.

Function

The ZNF143 protein is a transcription factor that binds to the SPH (Sp1 homology) motifs of many promoters. It is involved in various cellular processes, including cell cycle regulation, DNA replication, and embryonic development.

Structure

The ZNF143 gene is located on the short (p) arm of chromosome 11 at position 13.2. The protein encoded by this gene contains seven C2H2-type zinc fingers, which are the classic DNA-binding motifs of zinc finger proteins.

Clinical Significance

Mutations in the ZNF143 gene have been associated with various diseases. For instance, a recent study has linked ZNF143 mutations to neurodevelopmental disorders, including intellectual disability and autism spectrum disorder.

Research

Research on ZNF143 is ongoing, with scientists exploring its role in diseases such as cancer. Some studies suggest that ZNF143 may act as an oncogene, promoting the growth of cancer cells.

See Also

• Zinc finger protein
• Transcription factor
• Chromosome 11

References

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