CREB1

CREB1 (cAMP responsive element binding protein 1) is a protein that in humans is encoded by the CREB1 gene. It is a member of the leucine zipper family of DNA binding proteins and is a critical component of the cellular response to hormone stimulation and neuronal activity.

Function

CREB1 is a transcription factor that is activated by cAMP and calcium signaling pathways. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB1 is involved in a variety of cellular processes, including the survival of neurons, synaptic plasticity, and long-term memory.

Structure

The CREB1 protein consists of several domains: a kinase inducible domain (KID), a basic leucine zipper domain (bZIP), and a Q2 domain. The KID domain is responsible for the interaction with the coactivators CBP and p300, while the bZIP domain is responsible for DNA binding and dimerization.

Clinical significance

Mutations in the CREB1 gene have been associated with Rubinstein-Taybi syndrome, a condition characterized by intellectual disability and physical abnormalities. In addition, alterations in CREB1 function have been implicated in several neurological disorders, including Alzheimer's disease, depression, and drug addiction.

See also

• cAMP response element
• Transcription factor
• DNA binding protein
• Neuronal activity
• Hormone
• Protein
• Gene

References

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