Carbimazole

Carbimazole is an antithyroid medication commonly used to treat hyperthyroidism, a condition where the thyroid gland produces too much thyroid hormone. It works by reducing the production of thyroid hormones by the thyroid gland.

Mechanism of Action

Carbimazole is a prodrug that is converted to methimazole in the body. Methimazole inhibits the enzyme thyroid peroxidase, which is involved in the production of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). This results in a decrease in the production and release of thyroid hormones.

Uses

Carbimazole is primarily used in the treatment of hyperthyroidism. It may also be used before thyroid surgery or radioactive iodine therapy to reduce the levels of thyroid hormones.

Side Effects

Common side effects of carbimazole include nausea, vomiting, abdominal pain, headache, joint pain, and skin rash. Rare but serious side effects include agranulocytosis (a decrease in the number of white blood cells), hepatitis (inflammation of the liver), and neuropathy (nerve damage).

Contraindications

Carbimazole should not be used in people who are allergic to it or to any of the ingredients in the medication. It should also not be used in people with severe liver disease or blood disorders.

Interactions

Carbimazole can interact with several other medications, including warfarin, theophylline, and digoxin. It can also interact with food and alcohol.

Dosage

The dosage of carbimazole depends on the severity of the hyperthyroidism and the response to treatment. The initial dose is usually between 15 and 60 mg per day, divided into two or three doses. The maintenance dose is usually between 5 and 15 mg per day.

See Also

• Hyperthyroidism
• Thyroid hormones
• Antithyroid drugs

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Carbimazole

• Carbimazole chemical structure
  Carbimazole chemical structure