Ligustilide: Difference between revisions

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== Ligustilide ==


[[Ligustilide]] is a chemical compound that is found in certain plants, most notably in the [[Chinese herb]] [[Dong Quai]] (Angelica sinensis). It is classified as a [[phytochemical]], specifically a [[phthalide]], and is known for its various [[pharmacological]] effects.
{{Infobox chemical
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 477239679
| ImageFile = Ligustilide.png
| ImageSize = 200px
| ImageAlt =
| IUPACName = (3E)-3-butylidene-4,5-dihydro-2-benzofuran-1(3H)-one
| OtherNames =
| Section1 = {{Chembox Identifiers
  | CASNo_Ref =
  | CASNo = 4431-01-0
  | PubChem = 5281527
  | ChemSpiderID_Ref =
  | ChemSpiderID = 4445020
  | UNII_Ref =
  | UNII = 0F1Q7K6I0Q
  | ChEMBL_Ref =
  | ChEMBL = 4445020
  | SMILES = CCC=1C(=O)OC2=CC=CC=C2C1
  | InChI = 1S/C12H14O2/c1-2-3-8-11(13)14-12-7-5-4-6-10(8)9-12/h4-7,9H,2-3H2,1H3
  | InChIKey = YQKQXKZBWHZLEO-UHFFFAOYSA-N
}}
| Section2 = {{Chembox Properties
  | C=12
  | H=14
  | O=2
  | MolarMass = 190.24 g/mol
}}
}}


=== Chemical Structure ===
'''Ligustilide''' is a [[phthalide]] compound found in various [[medicinal plants]], particularly in the [[Apiaceae]] family. It is a major bioactive component of [[Angelica sinensis]], commonly known as [[Dong quai]], and [[Ligusticum chuanxiong]], known as [[Szechuan lovage]].


[[File:Ligustilide.png|thumb|right|Chemical structure of ligustilide]]
== Pharmacological Effects ==
Ligustilide is a phthalide, a type of organic compound that is characterized by a three-ring structure. Its chemical formula is C12H14O2. The compound is a yellowish oil that is soluble in [[ethanol]] and [[chloroform]], but insoluble in water.
Ligustilide has been studied for its potential [[pharmacological]] effects, including [[anti-inflammatory]], [[analgesic]], and [[neuroprotective]] properties. It is believed to contribute to the therapeutic effects of [[traditional Chinese medicine]] formulations that include [[Angelica sinensis]] and [[Ligusticum chuanxiong]].


=== Sources ===
=== Anti-inflammatory and Analgesic Effects ===
Research suggests that ligustilide may inhibit the production of [[pro-inflammatory cytokines]] and reduce [[pain]] by modulating [[neurotransmitter]] pathways. These effects make it a compound of interest for the development of new [[anti-inflammatory drugs]].


Ligustilide is primarily found in the root of the Dong Quai plant, but it can also be found in other plants in the [[Apiaceae]] family, such as [[lovage]] and [[celery]]. The concentration of ligustilide in these plants can vary depending on factors such as the plant's age and the environmental conditions in which it is grown.
=== Neuroprotective Effects ===
Ligustilide has shown potential in protecting [[neurons]] from [[oxidative stress]] and [[apoptosis]], which are key factors in [[neurodegenerative diseases]] such as [[Alzheimer's disease]] and [[Parkinson's disease]].


=== Pharmacological Effects ===
== Sources and Extraction ==
Ligustilide is primarily extracted from the roots of [[Angelica sinensis]] and [[Ligusticum chuanxiong]]. The extraction process typically involves the use of [[solvent extraction]] techniques to isolate the compound from the plant material.


Ligustilide has been studied for its potential [[medicinal]] benefits. It has been found to have [[anti-inflammatory]], [[antioxidant]], and [[antispasmodic]] properties. Some studies have also suggested that it may have [[anticancer]] effects, although more research is needed in this area.
== Safety and Toxicity ==
 
While ligustilide is generally considered safe when used in traditional [[herbal medicine]] practices, further studies are needed to fully understand its [[toxicological]] profile and potential [[side effects]] when used in higher concentrations or as an isolated compound.
In traditional Chinese medicine, Dong Quai is often used to treat conditions such as [[menstrual cramps]], [[anemia]], and [[high blood pressure]]. The presence of ligustilide in Dong Quai is believed to contribute to the herb's medicinal properties.
 
=== Safety and Side Effects ===
 
While ligustilide is generally considered safe when consumed in the amounts found in food, it can cause side effects in some people, especially when taken in large amounts or for a long period of time. These side effects can include [[nausea]], [[diarrhea]], and [[skin rash]]. Pregnant women should avoid consuming large amounts of ligustilide, as it can potentially cause [[miscarriage]].


== See Also ==
== See Also ==
* [[Phthalide]]
* [[Phthalide]]
* [[Dong Quai]]
* [[Angelica sinensis]]
* [[Phytochemical]]
* [[Ligusticum chuanxiong]]
* [[Traditional Chinese Medicine]]
* [[Traditional Chinese medicine]]


== References ==
== References ==
{{Reflist}}


{{reflist}}
== External Links ==
* [https://www.wikimd.com/wiki/Ligustilide Ligustilide on WikiMD]


[[Category:Phytochemicals]]
[[Category:Phthalides]]
[[Category:Traditional Chinese Medicine]]
[[Category:Medicinal chemistry]]
[[Category:Medicinal Plants]]
[[Category:Traditional Chinese medicine]]
{{medicine-stub}}
[[Category:Anti-inflammatory agents]]
[[Category:Neuroprotective agents]]
== Ligustilide ==
<gallery>
File:Ligustilide.svg|Ligustilide
</gallery>

Latest revision as of 23:57, 24 February 2025


Chemical Compound
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ChEBI
ChEMBL
Properties
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GHS Pictograms [[File:|50px]]
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NFPA 704 [[File:|50px]]
References

Ligustilide is a phthalide compound found in various medicinal plants, particularly in the Apiaceae family. It is a major bioactive component of Angelica sinensis, commonly known as Dong quai, and Ligusticum chuanxiong, known as Szechuan lovage.

Pharmacological Effects[edit]

Ligustilide has been studied for its potential pharmacological effects, including anti-inflammatory, analgesic, and neuroprotective properties. It is believed to contribute to the therapeutic effects of traditional Chinese medicine formulations that include Angelica sinensis and Ligusticum chuanxiong.

Anti-inflammatory and Analgesic Effects[edit]

Research suggests that ligustilide may inhibit the production of pro-inflammatory cytokines and reduce pain by modulating neurotransmitter pathways. These effects make it a compound of interest for the development of new anti-inflammatory drugs.

Neuroprotective Effects[edit]

Ligustilide has shown potential in protecting neurons from oxidative stress and apoptosis, which are key factors in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

Sources and Extraction[edit]

Ligustilide is primarily extracted from the roots of Angelica sinensis and Ligusticum chuanxiong. The extraction process typically involves the use of solvent extraction techniques to isolate the compound from the plant material.

Safety and Toxicity[edit]

While ligustilide is generally considered safe when used in traditional herbal medicine practices, further studies are needed to fully understand its toxicological profile and potential side effects when used in higher concentrations or as an isolated compound.

See Also[edit]

References[edit]

<references group="" responsive="1"></references>


External Links[edit]

Ligustilide[edit]

  • Ligustilide
    Ligustilide
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