VRK1

VRK1

Crystal structure of the human vaccinia-related kinase 1 (VRK1)

VRK1 (Vaccinia-related kinase 1) is a protein kinase that is part of the vaccinia-related kinase family. It plays a crucial role in various cellular processes, including cell cycle regulation, DNA damage response, and transcriptional control.

Function

VRK1 is involved in the regulation of the cell cycle, particularly in the transition from the G1 phase to the S phase. It phosphorylates several key proteins, including p53, a tumor suppressor protein, and histone H3, which is involved in chromatin remodeling. VRK1's activity is essential for proper cell division and proliferation.

Structure

The structure of VRK1 has been elucidated through X-ray crystallography, revealing its kinase domain and the specific sites for ATP binding and substrate interaction. The crystal structure provides insights into its enzymatic mechanism and potential targets for therapeutic intervention.

Clinical Significance

Mutations or dysregulation of VRK1 have been associated with various cancers and neurological disorders. VRK1 is considered a potential target for cancer therapy due to its role in cell proliferation and survival. Studies have shown that inhibiting VRK1 activity can lead to reduced tumor growth in certain cancer models.

Research

Ongoing research is focused on understanding the detailed mechanisms by which VRK1 regulates cellular processes and its interactions with other proteins. There is also interest in developing specific inhibitors that can modulate VRK1 activity for therapeutic purposes.

Related pages

• Protein kinase
• Cell cycle
• Tumor suppressor

VRK1

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  Crystal Structure of the Human vaccinia-related kinase