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{{short description|American biotherapeutics company}}
== ATyr Pharma ==
{{Use mdy dates|date=October 2023}}


'''ATyr Pharma''' is a biotherapeutics company focused on the discovery and development of innovative medicines based on novel biological pathways. The company is headquartered in San Diego, California, and is engaged in the research and development of therapies for patients with rare diseases and conditions characterized by severe immune dysregulation.
[[File:ATyr_Pharma_logo.svg|thumb|right|Logo of ATyr Pharma]]


==History==
'''ATyr Pharma''' is a biotechnology company focused on the discovery and development of innovative medicines based on novel biological pathways. The company is headquartered in [[San Diego, California]], and it specializes in the research of [[tRNA synthetase]] biology and its applications in treating various diseases.
ATyr Pharma was founded in 2005 with the aim of exploring the therapeutic potential of a newly discovered class of proteins known as [[tRNA synthetase]]s. These proteins are traditionally known for their role in [[protein synthesis]], but ATyr Pharma has been investigating their potential as signaling molecules in various biological processes.


==Research and Development==
=== History ===
The company's research focuses on the development of therapies that modulate the immune system. ATyr Pharma's lead therapeutic candidate is ATYR1923, a fusion protein designed to selectively modulate the immune response in inflammatory diseases. The company is exploring the use of ATYR1923 in conditions such as [[pulmonary sarcoidosis]], a rare inflammatory disease affecting the lungs.
ATyr Pharma was founded in 2005 by Dr. Paul Schimmel, a renowned scientist in the field of tRNA synthetase biology. The company was established to explore the therapeutic potential of proteins derived from tRNA synthetases, which are enzymes that play a crucial role in the translation of genetic information into proteins.


===tRNA Synthetase Biology===
=== Research and Development ===
ATyr Pharma's research is based on the novel understanding of tRNA synthetases beyond their canonical role in protein synthesis. These enzymes have been found to have additional functions in [[cell signaling]] and immune modulation. The company is leveraging this knowledge to develop new therapeutic approaches for diseases with unmet medical needs.
ATyr Pharma's research focuses on a class of proteins known as [[Physiocrines]], which are derived from tRNA synthetases. These proteins have been found to have diverse biological functions, including roles in [[immune modulation]], [[tissue regeneration]], and [[inflammation]]. The company is investigating these proteins as potential treatments for a variety of diseases, including [[pulmonary disease]], [[cancer]], and [[autoimmune disorders]].


==Clinical Trials==
=== Pipeline ===
ATyr Pharma is conducting clinical trials to evaluate the safety and efficacy of its lead candidate, ATYR1923. The company has completed Phase 1 clinical trials and is currently engaged in Phase 2 trials for the treatment of pulmonary sarcoidosis. These trials are designed to assess the drug's ability to reduce inflammation and improve lung function in affected patients.
The company's lead therapeutic candidate is ATYR1923, a fusion protein that targets the neuropilin-2 (NRP2) receptor. ATYR1923 is being developed for the treatment of interstitial lung diseases, including [[pulmonary sarcoidosis]] and other forms of [[fibrosis]].


==Collaborations and Partnerships==
=== Collaborations ===
ATyr Pharma has established collaborations with various academic and research institutions to advance its scientific understanding and therapeutic development. These partnerships are crucial for the company's efforts to translate its discoveries into clinical applications.
ATyr Pharma has established collaborations with several academic institutions and research organizations to advance its scientific discoveries. These partnerships aim to enhance the understanding of tRNA synthetase biology and accelerate the development of new therapeutic approaches.


==Corporate Structure==
=== Corporate Structure ===
The company is led by a team of experienced executives and scientists with expertise in biotechnology and drug development. ATyr Pharma is publicly traded on the [[NASDAQ]] stock exchange under the ticker symbol "LIFE."
The company is led by a team of experienced executives and scientists with expertise in biotechnology and drug development. ATyr Pharma is publicly traded on the [[NASDAQ]] stock exchange under the ticker symbol "LIFE."


==Related pages==
== Related pages ==
* [[Biotechnology]]
* [[Biotechnology]]
* [[tRNA synthetase]]
* [[Drug development]]
* [[Drug development]]
* [[Immune system]]
* [[Pulmonary disease]]
* [[Rare diseases]]


==Gallery==
[[Category:Biotechnology companies]]
<gallery>
[[Category:Companies based in San Diego, California]]
File:ATyr_Pharma_logo.svg|Logo of ATyr Pharma
[[Category:Pharmaceutical companies of the United States]]
</gallery>
 
[[Category:Biotechnology companies of the United States]]
[[Category:Companies based in San Diego]]
[[Category:Pharmaceutical companies established in 2005]]
[[Category:2005 establishments in California]]

Latest revision as of 11:04, 15 February 2025

ATyr Pharma[edit]

Logo of ATyr Pharma

ATyr Pharma is a biotechnology company focused on the discovery and development of innovative medicines based on novel biological pathways. The company is headquartered in San Diego, California, and it specializes in the research of tRNA synthetase biology and its applications in treating various diseases.

History[edit]

ATyr Pharma was founded in 2005 by Dr. Paul Schimmel, a renowned scientist in the field of tRNA synthetase biology. The company was established to explore the therapeutic potential of proteins derived from tRNA synthetases, which are enzymes that play a crucial role in the translation of genetic information into proteins.

Research and Development[edit]

ATyr Pharma's research focuses on a class of proteins known as Physiocrines, which are derived from tRNA synthetases. These proteins have been found to have diverse biological functions, including roles in immune modulation, tissue regeneration, and inflammation. The company is investigating these proteins as potential treatments for a variety of diseases, including pulmonary disease, cancer, and autoimmune disorders.

Pipeline[edit]

The company's lead therapeutic candidate is ATYR1923, a fusion protein that targets the neuropilin-2 (NRP2) receptor. ATYR1923 is being developed for the treatment of interstitial lung diseases, including pulmonary sarcoidosis and other forms of fibrosis.

Collaborations[edit]

ATyr Pharma has established collaborations with several academic institutions and research organizations to advance its scientific discoveries. These partnerships aim to enhance the understanding of tRNA synthetase biology and accelerate the development of new therapeutic approaches.

Corporate Structure[edit]

The company is led by a team of experienced executives and scientists with expertise in biotechnology and drug development. ATyr Pharma is publicly traded on the NASDAQ stock exchange under the ticker symbol "LIFE."

Related pages[edit]