Latamoxef: Difference between revisions

Latest revision as of 11:00, 15 February 2025

Latamoxef[edit]

Latamoxef, also known as moxalactam, is a beta-lactam antibiotic belonging to the oxacephem class. It is used in the treatment of various bacterial infections and is known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria.

Mechanism of Action[edit]

Latamoxef works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which are essential for the cross-linking of the peptidoglycan layer. This inhibition leads to the weakening of the cell wall and ultimately causes bacterial cell lysis and death.

Clinical Uses[edit]

Latamoxef is used to treat a variety of infections, including:

It is particularly useful in treating infections caused by Enterobacteriaceae and other resistant organisms.

Side Effects[edit]

Common side effects of latamoxef include:

Gastrointestinal disturbances such as nausea and diarrhea
Allergic reactions, including rash and anaphylaxis
Hematological effects such as thrombocytopenia and neutropenia

Synthesis[edit]

The synthesis of moxalactam involves the chemical modification of the beta-lactam core to include an oxacephem ring structure. This modification enhances its stability against beta-lactamases and broadens its antibacterial spectrum.

Related Pages[edit]

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-'''Latamoxef''' (or '''moxalactam''') is an [[antibiotic]] in the [[cephalosporin]] class. It is an oxacephem, a subclass of beta-lactam antibiotics that includes [[flomoxef]] and [[cefoperazone]]. Latamoxef was discovered by scientists at [[Shionogi]].
+== Latamoxef ==
-==Medical uses==
+[[File:Moxalactam_synthesis.svg|thumb|right|Synthesis of Moxalactam]]
-Latamoxef is used to treat severe infections caused by susceptible strains of [[microorganism]]s. It is particularly effective against [[gram-negative bacteria]], including [[Pseudomonas aeruginosa]], [[Escherichia coli]], and [[Klebsiella pneumoniae]]. It is also used in the treatment of [[septicemia]], [[meningitis]], and infections of the [[urinary tract]], [[respiratory tract]], [[skin and skin structure]], and [[intra-abdominal]] region.
-==Pharmacology==
+'''Latamoxef''', also known as '''moxalactam''', is a [[beta-lactam antibiotic]] belonging to the [[oxacephem]] class. It is used in the treatment of various bacterial infections and is known for its broad-spectrum activity against both [[Gram-positive bacteria|Gram-positive]] and [[Gram-negative bacteria]].
-Latamoxef is a broad-spectrum antibiotic that inhibits the synthesis of bacterial cell walls, leading to cell death. It is resistant to most beta-lactamases and is active against a wide range of gram-negative and gram-positive bacteria.
-==Side effects==
+== Mechanism of Action ==
-Common side effects of latamoxef include [[diarrhea]], [[nausea]], [[vomiting]], and [[rash]]. Less common side effects include [[anemia]], [[thrombocytopenia]], and [[leukopenia]]. In rare cases, latamoxef can cause serious allergic reactions.
-==History==
+Latamoxef works by inhibiting bacterial [[cell wall]] synthesis. It binds to [[penicillin-binding proteins]] (PBPs) located inside the bacterial cell wall, which are essential for the cross-linking of the [[peptidoglycan]] layer. This inhibition leads to the weakening of the cell wall and ultimately causes bacterial cell lysis and death.
-Latamoxef was discovered in the 1970s by scientists at Shionogi. It was approved for medical use in the United States in 1981.
-==See also==
+== Clinical Uses ==
-* [[List of antibiotics]]
-* [[Oxacephem]]
-* [[Cephalosporin]]
+Latamoxef is used to treat a variety of infections, including:
+* [[Urinary tract infections]]
+* [[Respiratory tract infections]]
+* [[Intra-abdominal infections]]
+* [[Skin and soft tissue infections]]
+It is particularly useful in treating infections caused by [[Enterobacteriaceae]] and other resistant organisms.
+== Side Effects ==
+Common side effects of latamoxef include:
+* [[Gastrointestinal disturbances]] such as [[nausea]] and [[diarrhea]]
+* [[Allergic reactions]], including [[rash]] and [[anaphylaxis]]
+* [[Hematological effects]] such as [[thrombocytopenia]] and [[neutropenia]]
+== Synthesis ==
+The synthesis of moxalactam involves the chemical modification of the beta-lactam core to include an oxacephem ring structure. This modification enhances its stability against beta-lactamases and broadens its antibacterial spectrum.
+== Related Pages ==
+* [[Beta-lactam antibiotics]]
+* [[Antibiotic resistance]]
+* [[Penicillin-binding proteins]]
+[[Category:Beta-lactam antibiotics]]
 [[Category:Antibiotics]]
-[[Category:Cephalosporin antibiotics]]
-[[Category:Shionogi]]
-{{stub}}