JWH-019: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{DISPLAYTITLE:JWH-019}} | |||
== | == Overview == | ||
JWH-019 is part of the naphthoylindole family of synthetic cannabinoids | '''JWH-019''' is a synthetic cannabinoid that acts as a potent agonist of the [[cannabinoid receptor|cannabinoid receptors]]. It is part of the naphthoylindole family of synthetic cannabinoids, which are often used in research to study the [[endocannabinoid system]]. | ||
== | == Chemical Structure == | ||
JWH-019 | [[File:JWH019.svg|thumb|right|Chemical structure of JWH-019]] | ||
JWH-019 is chemically classified as a naphthoylindole, with the full chemical name being 1-hexyl-3-(naphthalen-1-oyl)indole. The structure consists of a naphthalene group attached to an indole core, with a hexyl chain at the nitrogen atom of the indole. | |||
== | == Pharmacology == | ||
JWH-019 functions as a full agonist at both the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors. These receptors are part of the [[G protein-coupled receptor]] family and are primarily involved in the modulation of neurotransmitter release in the [[central nervous system]] and [[peripheral nervous system]]. | |||
== | === CB1 Receptor === | ||
The | The CB1 receptor is predominantly found in the brain and is responsible for the psychoactive effects of cannabinoids. JWH-019's interaction with this receptor can lead to effects similar to those of [[tetrahydrocannabinol|THC]], the primary psychoactive component of [[cannabis]]. | ||
== | === CB2 Receptor === | ||
The CB2 receptor is mainly located in the immune system and peripheral tissues. Activation of this receptor by JWH-019 can influence [[immune response]] and [[inflammation]]. | |||
== Legal Status == | |||
Due to its potential for abuse and lack of medical use, JWH-019 is classified as a controlled substance in many countries. It is often included in legislation targeting synthetic cannabinoids and "[[designer drugs]]." | |||
== Synthesis == | |||
The synthesis of JWH-019 involves the reaction of 1-naphthoyl chloride with 1-hexylindole in the presence of a base. This process is similar to the synthesis of other naphthoylindole cannabinoids, such as [[JWH-018]]. | |||
== Potential Effects and Risks == | |||
JWH-019, like other synthetic cannabinoids, can produce a range of effects including euphoria, altered perception, and relaxation. However, it can also lead to adverse effects such as anxiety, paranoia, and [[tachycardia]]. The long-term health effects of JWH-019 use are not well understood, and its use is associated with significant health risks. | |||
== Related Pages == | |||
* [[Synthetic cannabinoids]] | * [[Synthetic cannabinoids]] | ||
* [[Cannabinoid receptor]] | * [[Cannabinoid receptor]] | ||
* [[ | * [[JWH-018]] | ||
* [[Endocannabinoid system]] | |||
[[Category:Synthetic cannabinoids]] | [[Category:Synthetic cannabinoids]] | ||
[[Category:Designer drugs]] | [[Category:Designer drugs]] | ||
Latest revision as of 03:47, 13 February 2025
Overview[edit]
JWH-019 is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of the naphthoylindole family of synthetic cannabinoids, which are often used in research to study the endocannabinoid system.
Chemical Structure[edit]
JWH-019 is chemically classified as a naphthoylindole, with the full chemical name being 1-hexyl-3-(naphthalen-1-oyl)indole. The structure consists of a naphthalene group attached to an indole core, with a hexyl chain at the nitrogen atom of the indole.
Pharmacology[edit]
JWH-019 functions as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the G protein-coupled receptor family and are primarily involved in the modulation of neurotransmitter release in the central nervous system and peripheral nervous system.
CB1 Receptor[edit]
The CB1 receptor is predominantly found in the brain and is responsible for the psychoactive effects of cannabinoids. JWH-019's interaction with this receptor can lead to effects similar to those of THC, the primary psychoactive component of cannabis.
CB2 Receptor[edit]
The CB2 receptor is mainly located in the immune system and peripheral tissues. Activation of this receptor by JWH-019 can influence immune response and inflammation.
Legal Status[edit]
Due to its potential for abuse and lack of medical use, JWH-019 is classified as a controlled substance in many countries. It is often included in legislation targeting synthetic cannabinoids and "designer drugs."
Synthesis[edit]
The synthesis of JWH-019 involves the reaction of 1-naphthoyl chloride with 1-hexylindole in the presence of a base. This process is similar to the synthesis of other naphthoylindole cannabinoids, such as JWH-018.
Potential Effects and Risks[edit]
JWH-019, like other synthetic cannabinoids, can produce a range of effects including euphoria, altered perception, and relaxation. However, it can also lead to adverse effects such as anxiety, paranoia, and tachycardia. The long-term health effects of JWH-019 use are not well understood, and its use is associated with significant health risks.
