Editing ID4

'''ID4''' or '''Inhibitor of DNA binding 4''' is a [[protein]] that in humans is encoded by the ''ID4'' [[gene]]. It is a member of the [[inhibitor of DNA binding]] family, members of which are transcriptional regulators that contain a [[helix-loop-helix]] (HLH) domain but not a basic domain. 

== Function ==

Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A [[mutation]] in this gene has been associated with a specific type of [[adenocarcinoma]].

== Clinical significance ==

ID4 has been implicated in various types of [[cancer]], including [[breast cancer]], [[ovarian cancer]], and [[glioblastoma]]. It is thought to act as a [[tumor suppressor]] in some contexts, but may promote cancer growth in others. The exact mechanisms by which ID4 influences cancer development and progression are still being investigated.

== See also ==
* [[Inhibitor of DNA binding]]
* [[Helix-loop-helix]]
* [[Adenocarcinoma]]
* [[Tumor suppressor]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/ID4 ID4] at the [[National Center for Biotechnology Information]]

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[[Category:Transcription factors]]
[[Category:Human proteins]]
[[Category:Genes]]
[[Category:Oncology]]
[[Category:Medical genetics]]
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